Matches in SemOpenAlex for { <https://semopenalex.org/work/W1498789585> ?p ?o ?g. }
- W1498789585 endingPage "436" @default.
- W1498789585 startingPage "427" @default.
- W1498789585 abstract "The specificity of five monoclonal antibodies (P1-P6) against platelet surface components was determined by immunoprecipitation of surface-labelled platelets from normal donors and patients with known platelet glycoprotein defects, followed by analysis by gel electrophoresis. Three (P2, P4 and P6) precipitated glycoproteins IIb and IIIa and, in addition, P2 precipitated glycoprotein Ia. P1 precipitated normally only glycoprotein Ib also Ia when the platelets were pretreated with neuraminidase. P3 precipitated principally glycoprotein Ia but glycoprotein Ib was also weakly precipitated. The effects of the monoclonals on platelet function were tested. P1 and P2 completely inhibited and P3 slightly inhibited thrombin-induced platelet aggregation. P2 also inhibited collagen-induced aggregation and partially inhibited ADP-induced platelet aggregation. P3, P4 and P6 partially inhibited ADP-induced platelet aggregation. None had any effect on ristocetin-induced aggregation despite P1 and P3 binding to glycoprotein Ib. These results confirm the role of glycoproteins IIb and IIIa in aggregation induced by various agents and suggest that the function of glycoprotein Ib in thrombin-induced aggregation is more important than previously suspected and that glycoprotein Ia may also be involved in platelet functions." @default.
- W1498789585 created "2016-06-24" @default.
- W1498789585 creator A5006904490 @default.
- W1498789585 creator A5022900584 @default.
- W1498789585 creator A5026818556 @default.
- W1498789585 creator A5028122476 @default.
- W1498789585 creator A5052987585 @default.
- W1498789585 creator A5055254464 @default.
- W1498789585 creator A5083334978 @default.
- W1498789585 creator A5088593755 @default.
- W1498789585 creator A5088635360 @default.
- W1498789585 date "1983-03-01" @default.
- W1498789585 modified "2023-10-01" @default.
- W1498789585 title "Monoclonal Antibodies against Platelet Membrane Glycoproteins. Characterization and Effect on Platelet Function" @default.
- W1498789585 cites W1505489415 @default.
- W1498789585 cites W1522420709 @default.
- W1498789585 cites W1540614542 @default.
- W1498789585 cites W1545341742 @default.
- W1498789585 cites W1556035179 @default.
- W1498789585 cites W1588885776 @default.
- W1498789585 cites W1606423922 @default.
- W1498789585 cites W1775749144 @default.
- W1498789585 cites W1923932475 @default.
- W1498789585 cites W1936995585 @default.
- W1498789585 cites W1974146559 @default.
- W1498789585 cites W1974869964 @default.
- W1498789585 cites W1975542913 @default.
- W1498789585 cites W1977303503 @default.
- W1498789585 cites W1977461031 @default.
- W1498789585 cites W1980188591 @default.
- W1498789585 cites W1983654684 @default.
- W1498789585 cites W1987262605 @default.
- W1498789585 cites W2006799862 @default.
- W1498789585 cites W2006893501 @default.
- W1498789585 cites W2009763777 @default.
- W1498789585 cites W2009967151 @default.
- W1498789585 cites W2014166250 @default.
- W1498789585 cites W2023607502 @default.
- W1498789585 cites W2024096897 @default.
- W1498789585 cites W2026146058 @default.
- W1498789585 cites W2030522563 @default.
- W1498789585 cites W2030788674 @default.
- W1498789585 cites W2032030205 @default.
- W1498789585 cites W2033785962 @default.
- W1498789585 cites W2034277598 @default.
- W1498789585 cites W2044649973 @default.
- W1498789585 cites W2049692254 @default.
- W1498789585 cites W2051430573 @default.
- W1498789585 cites W2052094977 @default.
- W1498789585 cites W2062147146 @default.
- W1498789585 cites W2074437277 @default.
- W1498789585 cites W2075137680 @default.
- W1498789585 cites W2078328099 @default.
- W1498789585 cites W2078593416 @default.
- W1498789585 cites W2080226094 @default.
- W1498789585 cites W2080990211 @default.
- W1498789585 cites W2085727695 @default.
- W1498789585 cites W2085760868 @default.
- W1498789585 cites W2093309976 @default.
- W1498789585 cites W2096835475 @default.
- W1498789585 cites W2100837269 @default.
- W1498789585 cites W2141436795 @default.
- W1498789585 cites W2155911050 @default.
- W1498789585 cites W2158963370 @default.
- W1498789585 cites W2168110441 @default.
- W1498789585 cites W2258528653 @default.
- W1498789585 cites W2416670731 @default.
- W1498789585 cites W2943108987 @default.
- W1498789585 cites W4239882846 @default.
- W1498789585 doi "https://doi.org/10.1111/j.1432-1033.1983.tb07281.x" @default.
- W1498789585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6832159" @default.
- W1498789585 hasPublicationYear "1983" @default.
- W1498789585 type Work @default.
- W1498789585 sameAs 1498789585 @default.
- W1498789585 citedByCount "108" @default.
- W1498789585 countsByYear W14987895852012 @default.
- W1498789585 countsByYear W14987895852017 @default.
- W1498789585 crossrefType "journal-article" @default.
- W1498789585 hasAuthorship W1498789585A5006904490 @default.
- W1498789585 hasAuthorship W1498789585A5022900584 @default.
- W1498789585 hasAuthorship W1498789585A5026818556 @default.
- W1498789585 hasAuthorship W1498789585A5028122476 @default.
- W1498789585 hasAuthorship W1498789585A5052987585 @default.
- W1498789585 hasAuthorship W1498789585A5055254464 @default.
- W1498789585 hasAuthorship W1498789585A5083334978 @default.
- W1498789585 hasAuthorship W1498789585A5088593755 @default.
- W1498789585 hasAuthorship W1498789585A5088635360 @default.
- W1498789585 hasConcept C104317684 @default.
- W1498789585 hasConcept C108625454 @default.
- W1498789585 hasConcept C116084860 @default.
- W1498789585 hasConcept C134164806 @default.
- W1498789585 hasConcept C14036430 @default.
- W1498789585 hasConcept C153911025 @default.
- W1498789585 hasConcept C159654299 @default.
- W1498789585 hasConcept C181199279 @default.
- W1498789585 hasConcept C185592680 @default.
- W1498789585 hasConcept C203014093 @default.
- W1498789585 hasConcept C26828662 @default.