FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1498821897> ?p ?o ?g. }

• W1498821897 endingPage "10119" @default.
• W1498821897 startingPage "10113" @default.
• W1498821897 abstract "Saccharomyces cerevisiae VMA genes, encoding essential components for the expression of vacuolar membrane H+-ATPase activity, are involved in intracellular ionic homeostasis and vacuolar biogenesis. We report here that the immunosuppressants FK506 and cyclosporin A cause general growth inhibition of the vma3 mutant. Upon addition of the drugs, the mutant grew neither in the presence of more than 5 mM Ca2+nor above pH 6.0. The action of the immunosuppressants is dependent on their binding proteins and ascribable to inhibition of calcineurin activity; a mutation of a calcineurin subunit (cnb1) shows synthetic lethal interaction with the vma mutation. The addition of FK506 decreases the cytosolic free concentration of Ca2+in the vma3 mutant cells. Consequently, FK506 induces an 8.9-fold elevation of a nonexchangeable Ca2+pool. These results suggest that calcineurin controls calcium homeostasis by repression of Ca2+flux into a cellular compartment(s) and that the vacuolar H+-ATPase is essential for cell growth cooperating with calcineurin to regulate the cytosolic free concentration of Ca2+. Saccharomyces cerevisiae VMA genes, encoding essential components for the expression of vacuolar membrane H+-ATPase activity, are involved in intracellular ionic homeostasis and vacuolar biogenesis. We report here that the immunosuppressants FK506 and cyclosporin A cause general growth inhibition of the vma3 mutant. Upon addition of the drugs, the mutant grew neither in the presence of more than 5 mM Ca2+nor above pH 6.0. The action of the immunosuppressants is dependent on their binding proteins and ascribable to inhibition of calcineurin activity; a mutation of a calcineurin subunit (cnb1) shows synthetic lethal interaction with the vma mutation. The addition of FK506 decreases the cytosolic free concentration of Ca2+in the vma3 mutant cells. Consequently, FK506 induces an 8.9-fold elevation of a nonexchangeable Ca2+pool. These results suggest that calcineurin controls calcium homeostasis by repression of Ca2+flux into a cellular compartment(s) and that the vacuolar H+-ATPase is essential for cell growth cooperating with calcineurin to regulate the cytosolic free concentration of Ca2+." @default.
• W1498821897 created "2016-06-24" @default.
• W1498821897 creator A5037124254 @default.
• W1498821897 creator A5042184135 @default.
• W1498821897 creator A5051850457 @default.
• W1498821897 creator A5060486921 @default.
• W1498821897 creator A5062148063 @default.
• W1498821897 date "1995-04-01" @default.
• W1498821897 modified "2023-10-15" @default.
• W1498821897 title "Cooperation of Calcineurin and Vacuolar H+-ATPase in Intracellular Ca2+Homeostasis of Yeast Cells" @default.
• W1498821897 cites W1479799584 @default.
• W1498821897 cites W1488647821 @default.
• W1498821897 cites W1501217717 @default.
• W1498821897 cites W1522668252 @default.
• W1498821897 cites W1531514263 @default.
• W1498821897 cites W1535401962 @default.
• W1498821897 cites W1556265505 @default.
• W1498821897 cites W1592537807 @default.
• W1498821897 cites W1647306826 @default.
• W1498821897 cites W166674927 @default.
• W1498821897 cites W19446119 @default.
• W1498821897 cites W1970705112 @default.
• W1498821897 cites W1970842110 @default.
• W1498821897 cites W1974750678 @default.
• W1498821897 cites W1982309241 @default.
• W1498821897 cites W1982869248 @default.
• W1498821897 cites W1984754431 @default.
• W1498821897 cites W1985339191 @default.
• W1498821897 cites W2016397692 @default.
• W1498821897 cites W2020524491 @default.
• W1498821897 cites W2041512157 @default.
• W1498821897 cites W2050695823 @default.
• W1498821897 cites W2060649120 @default.
• W1498821897 cites W2067119870 @default.
• W1498821897 cites W2108367015 @default.
• W1498821897 cites W2108794906 @default.
• W1498821897 cites W2123738381 @default.
• W1498821897 cites W2141260882 @default.
• W1498821897 cites W2156442455 @default.
• W1498821897 cites W2169333620 @default.
• W1498821897 cites W2176061808 @default.
• W1498821897 cites W4214500038 @default.
• W1498821897 doi "https://doi.org/10.1074/jbc.270.17.10113" @default.
• W1498821897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7537264" @default.
• W1498821897 hasPublicationYear "1995" @default.
• W1498821897 type Work @default.
• W1498821897 sameAs 1498821897 @default.
• W1498821897 citedByCount "82" @default.
• W1498821897 countsByYear W14988218972012 @default.
• W1498821897 countsByYear W14988218972013 @default.
• W1498821897 countsByYear W14988218972015 @default.
• W1498821897 countsByYear W14988218972016 @default.
• W1498821897 countsByYear W14988218972017 @default.
• W1498821897 countsByYear W14988218972019 @default.
• W1498821897 crossrefType "journal-article" @default.
• W1498821897 hasAuthorship W1498821897A5037124254 @default.
• W1498821897 hasAuthorship W1498821897A5042184135 @default.
• W1498821897 hasAuthorship W1498821897A5051850457 @default.
• W1498821897 hasAuthorship W1498821897A5060486921 @default.
• W1498821897 hasAuthorship W1498821897A5062148063 @default.
• W1498821897 hasBestOaLocation W14988218971 @default.
• W1498821897 hasConcept C102568950 @default.
• W1498821897 hasConcept C104317684 @default.
• W1498821897 hasConcept C128057223 @default.
• W1498821897 hasConcept C141071460 @default.
• W1498821897 hasConcept C143065580 @default.
• W1498821897 hasConcept C181199279 @default.
• W1498821897 hasConcept C185592680 @default.
• W1498821897 hasConcept C190062978 @default.
• W1498821897 hasConcept C191678065 @default.
• W1498821897 hasConcept C23265538 @default.
• W1498821897 hasConcept C2777576037 @default.
• W1498821897 hasConcept C2779222958 @default.
• W1498821897 hasConcept C2911091166 @default.
• W1498821897 hasConcept C55493867 @default.
• W1498821897 hasConcept C63645605 @default.
• W1498821897 hasConcept C71924100 @default.
• W1498821897 hasConcept C79879829 @default.
• W1498821897 hasConcept C86803240 @default.
• W1498821897 hasConcept C95444343 @default.
• W1498821897 hasConcept C98539663 @default.
• W1498821897 hasConceptScore W1498821897C102568950 @default.
• W1498821897 hasConceptScore W1498821897C104317684 @default.
• W1498821897 hasConceptScore W1498821897C128057223 @default.
• W1498821897 hasConceptScore W1498821897C141071460 @default.
• W1498821897 hasConceptScore W1498821897C143065580 @default.
• W1498821897 hasConceptScore W1498821897C181199279 @default.
• W1498821897 hasConceptScore W1498821897C185592680 @default.
• W1498821897 hasConceptScore W1498821897C190062978 @default.
• W1498821897 hasConceptScore W1498821897C191678065 @default.
• W1498821897 hasConceptScore W1498821897C23265538 @default.
• W1498821897 hasConceptScore W1498821897C2777576037 @default.
• W1498821897 hasConceptScore W1498821897C2779222958 @default.
• W1498821897 hasConceptScore W1498821897C2911091166 @default.
• W1498821897 hasConceptScore W1498821897C55493867 @default.
• W1498821897 hasConceptScore W1498821897C63645605 @default.
• W1498821897 hasConceptScore W1498821897C71924100 @default.
• W1498821897 hasConceptScore W1498821897C79879829 @default.

• next