FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1498846843> ?p ?o ?g. }

• W1498846843 endingPage "4467" @default.
• W1498846843 startingPage "4459" @default.
• W1498846843 abstract "Cells that acquire multidrug resistance (MDR) are characterized by a decreased accumulation of a variety of drugs. In addition, sequestration of drugs in intracellular vesicles has often been associated with MDR. However, the nature and role of intracellular vesicles in MDR are unclear. We addressed the relationship between MDR and vesicular anthracycline accumulation in the erythroleukemia cell line K562 and a drug-resistant counterpart K562/ADR that overexpresses P-glycoprotein. We used four anthracyclines (all of which are P-glycoprotein substrates): daunorubicin and idarubicin, which have good affinity for DNA and as weak bases can accumulate inside acidic compartments; hydroxyrubicin, which binds to DNA but is uncharged at physiological or acidic pH and thus cannot accumulate in acidic compartments; and WP900, an enantiomer of daunorubicin, which is a weak DNA binder but has the same pKa and lipophilicity as daunorubicin. The intrinsic fluorescence of anthracyclines allowed us to use macro- and micro-spectrofluorescence, flow cytometry, and confocal microscopy to characterize their nuclear or intravesicular accumulation in living cells. We found that vesicular accumulation of daunorubicin, WP900 and idarubicin, containing a basic 3′-amine was predominantly restricted to lysosomes in both cell lines, that pH regulation of acidic compartments was not defective in human K562 cells, and that vesicular drug accumulation was much more pronounced in the parental tumor cell line than in the multidrug-resistant cells. These results indicate that vesicular anthracycline sequestration does not contribute to the diminished sensitivity to anthracyclines in multidrug-resistant K562 cells." @default.
• W1498846843 created "2016-06-24" @default.
• W1498846843 creator A5004163998 @default.
• W1498846843 creator A5012691010 @default.
• W1498846843 creator A5062959791 @default.
• W1498846843 date "2001-08-15" @default.
• W1498846843 modified "2023-09-24" @default.
• W1498846843 title "Drug sequestration in cytoplasmic organelles does not contribute to the diminished sensitivity of anthracyclines in multidrug resistant K562 cells" @default.
• W1498846843 cites W100823820 @default.
• W1498846843 cites W1582548909 @default.
• W1498846843 cites W1867704953 @default.
• W1498846843 cites W1922557140 @default.
• W1498846843 cites W1981976352 @default.
• W1498846843 cites W1989174525 @default.
• W1498846843 cites W2004804291 @default.
• W1498846843 cites W2006176190 @default.
• W1498846843 cites W2008049857 @default.
• W1498846843 cites W2017319661 @default.
• W1498846843 cites W2025066311 @default.
• W1498846843 cites W2027690665 @default.
• W1498846843 cites W2028193434 @default.
• W1498846843 cites W2035501441 @default.
• W1498846843 cites W2042978626 @default.
• W1498846843 cites W2055299917 @default.
• W1498846843 cites W2067898376 @default.
• W1498846843 cites W2081604950 @default.
• W1498846843 cites W2089821200 @default.
• W1498846843 cites W2092688622 @default.
• W1498846843 cites W2096535122 @default.
• W1498846843 cites W2097878215 @default.
• W1498846843 cites W2098001162 @default.
• W1498846843 cites W2107132176 @default.
• W1498846843 cites W2118234018 @default.
• W1498846843 cites W2130277532 @default.
• W1498846843 cites W2168070336 @default.
• W1498846843 cites W2169403365 @default.
• W1498846843 cites W2619852674 @default.
• W1498846843 cites W4239139991 @default.
• W1498846843 cites W4249331303 @default.
• W1498846843 doi "https://doi.org/10.1046/j.1432-1327.2001.02370.x" @default.
• W1498846843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11502206" @default.
• W1498846843 hasPublicationYear "2001" @default.
• W1498846843 type Work @default.
• W1498846843 sameAs 1498846843 @default.
• W1498846843 citedByCount "14" @default.
• W1498846843 countsByYear W14988468432012 @default.
• W1498846843 countsByYear W14988468432018 @default.
• W1498846843 countsByYear W14988468432019 @default.
• W1498846843 countsByYear W14988468432020 @default.
• W1498846843 countsByYear W14988468432022 @default.
• W1498846843 countsByYear W14988468432023 @default.
• W1498846843 crossrefType "journal-article" @default.
• W1498846843 hasAuthorship W1498846843A5004163998 @default.
• W1498846843 hasAuthorship W1498846843A5012691010 @default.
• W1498846843 hasAuthorship W1498846843A5062959791 @default.
• W1498846843 hasBestOaLocation W14988468431 @default.
• W1498846843 hasConcept C121608353 @default.
• W1498846843 hasConcept C133936738 @default.
• W1498846843 hasConcept C1491633281 @default.
• W1498846843 hasConcept C171122931 @default.
• W1498846843 hasConcept C185592680 @default.
• W1498846843 hasConcept C203014093 @default.
• W1498846843 hasConcept C2776802502 @default.
• W1498846843 hasConcept C2778041864 @default.
• W1498846843 hasConcept C2778461978 @default.
• W1498846843 hasConcept C2778589691 @default.
• W1498846843 hasConcept C2778707650 @default.
• W1498846843 hasConcept C2779117419 @default.
• W1498846843 hasConcept C2781021840 @default.
• W1498846843 hasConcept C501593827 @default.
• W1498846843 hasConcept C530470458 @default.
• W1498846843 hasConcept C54355233 @default.
• W1498846843 hasConcept C55493867 @default.
• W1498846843 hasConcept C79879829 @default.
• W1498846843 hasConcept C81885089 @default.
• W1498846843 hasConcept C86803240 @default.
• W1498846843 hasConcept C95444343 @default.
• W1498846843 hasConcept C98274493 @default.
• W1498846843 hasConceptScore W1498846843C121608353 @default.
• W1498846843 hasConceptScore W1498846843C133936738 @default.
• W1498846843 hasConceptScore W1498846843C1491633281 @default.
• W1498846843 hasConceptScore W1498846843C171122931 @default.
• W1498846843 hasConceptScore W1498846843C185592680 @default.
• W1498846843 hasConceptScore W1498846843C203014093 @default.
• W1498846843 hasConceptScore W1498846843C2776802502 @default.
• W1498846843 hasConceptScore W1498846843C2778041864 @default.
• W1498846843 hasConceptScore W1498846843C2778461978 @default.
• W1498846843 hasConceptScore W1498846843C2778589691 @default.
• W1498846843 hasConceptScore W1498846843C2778707650 @default.
• W1498846843 hasConceptScore W1498846843C2779117419 @default.
• W1498846843 hasConceptScore W1498846843C2781021840 @default.
• W1498846843 hasConceptScore W1498846843C501593827 @default.
• W1498846843 hasConceptScore W1498846843C530470458 @default.
• W1498846843 hasConceptScore W1498846843C54355233 @default.
• W1498846843 hasConceptScore W1498846843C55493867 @default.
• W1498846843 hasConceptScore W1498846843C79879829 @default.
• W1498846843 hasConceptScore W1498846843C81885089 @default.
• W1498846843 hasConceptScore W1498846843C86803240 @default.

• next