Matches in SemOpenAlex for { <https://semopenalex.org/work/W1498962687> ?p ?o ?g. }
- W1498962687 abstract "Obesity is associated with a high prevalence of mood disorders and cognitive dysfunctions in addition to being a significant risk factor for important health complications such as cardiovascular diseases and type 2 diabetes. Identifying the pathophysiological mechanisms underlying these health issues is a major public health challenge. Based on recent findings, from studies conducted on animal models of obesity, it has been proposed that inflammatory processes may participate in both the peripheral and brain disorders associated with the obesity condition including the development of emotional and cognitive alterations. This is supported by the fact that obesity is characterized by peripheral low-grade inflammation, originating from increased adipose tissue mass and/or dysbiosis (changes in gut microbiota environment), both of which contribute to increased susceptibility to immune-mediated diseases. In this review, we provide converging evidence showing that obesity is associated with exacerbated neuroinflammation leading to dysfunction in vulnerable brain regions associated with mood regulation, learning, and memory such as the hippocampus. These findings give new insights to the pathophysiological mechanisms contributing to the development of brain disorders in the context of obesity and provide valuable data for introducing new therapeutic strategies for the treatment of neuropsychiatric complications often reported in obese patients." @default.
- W1498962687 created "2016-06-24" @default.
- W1498962687 creator A5010610547 @default.
- W1498962687 creator A5054453579 @default.
- W1498962687 creator A5062064926 @default.
- W1498962687 date "2015-07-03" @default.
- W1498962687 modified "2023-10-09" @default.
- W1498962687 title "Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity" @default.
- W1498962687 cites W1504872638 @default.
- W1498962687 cites W1505097575 @default.
- W1498962687 cites W1511961767 @default.
- W1498962687 cites W1535378236 @default.
- W1498962687 cites W1578273550 @default.
- W1498962687 cites W1604789859 @default.
- W1498962687 cites W1861219352 @default.
- W1498962687 cites W1933841656 @default.
- W1498962687 cites W1963550822 @default.
- W1498962687 cites W1964562779 @default.
- W1498962687 cites W1966233473 @default.
- W1498962687 cites W1967075670 @default.
- W1498962687 cites W1967351112 @default.
- W1498962687 cites W1969307610 @default.
- W1498962687 cites W1969631212 @default.
- W1498962687 cites W1970070704 @default.
- W1498962687 cites W1971420166 @default.
- W1498962687 cites W1973077616 @default.
- W1498962687 cites W1973172818 @default.
- W1498962687 cites W1973807988 @default.
- W1498962687 cites W1977983363 @default.
- W1498962687 cites W1978047273 @default.
- W1498962687 cites W1978557479 @default.
- W1498962687 cites W1978589950 @default.
- W1498962687 cites W1981500982 @default.
- W1498962687 cites W1982119998 @default.
- W1498962687 cites W1982754908 @default.
- W1498962687 cites W1985718159 @default.
- W1498962687 cites W1985790075 @default.
- W1498962687 cites W1986043736 @default.
- W1498962687 cites W1987248538 @default.
- W1498962687 cites W1993305928 @default.
- W1498962687 cites W1993306791 @default.
- W1498962687 cites W1993606536 @default.
- W1498962687 cites W1993870556 @default.
- W1498962687 cites W1994174603 @default.
- W1498962687 cites W1998558885 @default.
- W1498962687 cites W2000849147 @default.
- W1498962687 cites W2001807421 @default.
- W1498962687 cites W2001809220 @default.
- W1498962687 cites W2002201827 @default.
- W1498962687 cites W2003318621 @default.
- W1498962687 cites W2004415631 @default.
- W1498962687 cites W2004462939 @default.
- W1498962687 cites W2004864469 @default.
- W1498962687 cites W2008202586 @default.
- W1498962687 cites W2009064331 @default.
- W1498962687 cites W2009259412 @default.
- W1498962687 cites W2009491836 @default.
- W1498962687 cites W2010502598 @default.
- W1498962687 cites W2012464008 @default.
- W1498962687 cites W2013101568 @default.
- W1498962687 cites W2013776157 @default.
- W1498962687 cites W2014439734 @default.
- W1498962687 cites W2015725986 @default.
- W1498962687 cites W2017423317 @default.
- W1498962687 cites W2017661386 @default.
- W1498962687 cites W2019307401 @default.
- W1498962687 cites W2019735686 @default.
- W1498962687 cites W2022766686 @default.
- W1498962687 cites W2022900954 @default.
- W1498962687 cites W2025129891 @default.
- W1498962687 cites W2025875119 @default.
- W1498962687 cites W2026947991 @default.
- W1498962687 cites W2027727389 @default.
- W1498962687 cites W2030373374 @default.
- W1498962687 cites W2033028677 @default.
- W1498962687 cites W2034355214 @default.
- W1498962687 cites W2034735484 @default.
- W1498962687 cites W2034888144 @default.
- W1498962687 cites W2035717344 @default.
- W1498962687 cites W2037910836 @default.
- W1498962687 cites W2039414363 @default.
- W1498962687 cites W2045938350 @default.
- W1498962687 cites W2047021244 @default.
- W1498962687 cites W2047539013 @default.
- W1498962687 cites W2048545238 @default.
- W1498962687 cites W2049971830 @default.
- W1498962687 cites W2050508296 @default.
- W1498962687 cites W2051597542 @default.
- W1498962687 cites W2053257768 @default.
- W1498962687 cites W2054475219 @default.
- W1498962687 cites W2056481181 @default.
- W1498962687 cites W2057119181 @default.
- W1498962687 cites W2058344299 @default.
- W1498962687 cites W2058463332 @default.
- W1498962687 cites W2058606198 @default.
- W1498962687 cites W2058838792 @default.
- W1498962687 cites W2058960738 @default.
- W1498962687 cites W2059053486 @default.
- W1498962687 cites W2059416963 @default.
- W1498962687 cites W2059892950 @default.