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- W1498974772 abstract "This chapter focuses on structure-based drug design, which is a general term for using protein structural information from X-ray crystallography or NMR spectroscopy to assist in the design of novel therapeutic agents. Structure-based drug design is currently most applicable to developing inhibitors that bind to enzymes. Overall, approximately one-third of marketed drugs function primarily through direct inhibition of enzyme activity. Over 200 enzymes have been proposed as therapeutic targets within the pharmaceutical industry. New enzyme inhibitors have great potential to become therapeutically useful in the clinic and successful in the market. Detailed analysis of drug targets indicates that they cover a very broad spectrum of enzyme activities as well as being structurally diverse. This implies that efficient enzyme inhibitor design requires flexibility in the implementation of enzymatic assays as well as an appreciation of the subtleties of protein structure. The chapter reviews recent examples of the design of drugs that inhibit enzymes of therapeutic interest. An overview of structural genomics and structure-based drug design in presented and diverse structures and functions of therapeutically relevant targets are also explained." @default.
- W1498974772 created "2016-06-24" @default.
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- W1498974772 date "1999-01-01" @default.
- W1498974772 modified "2023-10-09" @default.
- W1498974772 title "Chapter 29. Structure-Based Drug Design" @default.
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- W1498974772 doi "https://doi.org/10.1016/s0065-7743(08)60591-6" @default.
- W1498974772 hasPublicationYear "1999" @default.
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