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- W1498979776 abstract "A simple and sensitive spectrophotometric method for the assay of two antihistamines, astemizole and loratadine, is described. The determination was based on the formation of charge- transfer complexes between chloranilic acid as a p - acceptor and the studied drugs as n-donors in acetonitrile solvent. The spectra, various experimental parameters, composition and formation constant of the complexes were studied. The formation constant (K) values of CT complex with astemizole were 0.9x10 3 and 1.06x10 3 calculated from Benesi-Hildebrand plot and from Turner and Anderson plot, respectively, whereas the corresponding values for loratadine were 4.50x10 3 and 4.19x10 3 , respectively. The charge-transfer complexes formed were found to absorb at 520 nm. Beer's law was obeyed in the concentration range 10 - 120 and 15 - 210 µg ml -1 for astemizole and loratadine respectively. The apparent molar absorptivity and Sandell sensitivity values were 1.78x10 3 and 0.96x10 3 l mol -1 cm -1 and 257.62 and 396.61 ng cm -2 , for astemizole and loratadine, respectively. The limits of detection and quantification for astemizole were 1.05 and 3.51 µg ml -1 , respectively; the corresponding values for loratadine were 2.21 and 7.39 µg ml -1 respectively. The method was applied to the determination of the studied drugs in several of their commercial preparations and the results were statistically validated. Excipients used as additives in commercial formulations did not interfere in the proposed procedure." @default.
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- W1498979776 date "2002-01-01" @default.
- W1498979776 modified "2023-09-26" @default.
- W1498979776 title "Spectrophotometric determination of astemizole and loratadine based on charge-transfer complex formation with chloranilic acid." @default.
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