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• W1498982491 abstract "Lymphomas encompass a group of malignancies that originate in the lymph nodes or other lymphoid tissues. Epigenetic modification, especially by histone deacetylase (HDACs), plays a key role during the occurrence and development of lymphomas. Consequently, HDAC inhibitors (HDACIs), a class of gene expression-modulating drugs, have emerged as promising mechanism-based agents for the treatment of lymphomas. This review presents the rationale of HDAC inhibition, describes the epigenetic-based mechanisms of action of HDACIs, discusses their clinical efficiency, and summarizes the current and future developments in this field." @default.
• W1498982491 created "2016-06-24" @default.
• W1498982491 creator A5038033448 @default.
• W1498982491 creator A5085410358 @default.
• W1498982491 date "2012-06-01" @default.
• W1498982491 modified "2023-09-23" @default.
• W1498982491 title "Histone deacetylase inhibition: an important mechanism in the treatment of lymphoma." @default.
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• W1498982491 doi "https://doi.org/10.3969/j.issn.2095-3941.2012.02.001" @default.
• W1498982491 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3643654" @default.
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