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• W1499003045 abstract "Abstract The effect of intracellular Ca 2+ increase was analysed in isolated frog taste cells under the whole‐cell patch clamp. External application of a Ca 2+ ‐ionophore, ionomycin (3 μ m ) induced the sustained inward current of −200 ± 17 pA (mean ± SE, n = 23) at – 50 mV in taste cells. The ionomycin‐induced response was observed in most of the cells exposed in the drug, but not when 10 m m BAPTA (1,2‐bis ( o ‐aminophenoxy)ethane‐ N , N , N ′, N ′‐tetraacetic acid) was included in the pipette (eight cells). Steady‐state I–V relationships of ionomycin‐induced currents were almost linear and reversed at – 8 ± 1 mV ( n = 23). The simultaneous removal of Na + and Ca 2+ from the external solution eliminated the response completely (three cells). Intracellular dialysis with 1 m m Ca 2+ or 50 μ m inositol 1,4,5‐trisphosphate (IP 3 ) in K + ‐internal solution also induced an inward current in the taste cells. The Ca 2+ ‐induced and IP 3 ‐induced responses were observed in 82% and 36% of the cells dialysed with the drugs, respectively. The Ca 2+ ‐induced and IP 3 ‐induced currents were inhibited by external Cd 2+ (1–2 m m ). The reversal potentials of the inward currents were – 15 ± 3 mV ( n = 9) in Ca 2+ dialysis and – 11 ± 3 mV ( n = 13) in IP 3 dialysis. The half‐maximal Ca 2+ concentration in the pipette to induce the inward current was ≈ 170 μ m . The results suggest that IP 3 can depolarize the taste cell with mediation by intracellular Ca 2+ ." @default.
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• W1499003045 date "1998-04-01" @default.
• W1499003045 modified "2023-10-17" @default.
• W1499003045 title "Inositol 1,4,5-trisphosphate activates non-selective cation conductance via intracellular Ca2+ increase in isolated frog taste cells" @default.
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• W1499003045 doi "https://doi.org/10.1046/j.1460-9568.1998.00151.x" @default.
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