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• W1499053463 abstract "Abstract : Our data demonstrates that WBP-2 is recruited onto the hormone responsive promoters in the presence of hormone and it specifically enhances the transactivation functions of PR and ER. Our data also demonstrates that WBP-2 contains an intrinsic activation domain and the cPPXY of WBP-2 is essential for its coactivation and intrinsic activation functions. Our preliminary data also demonstrates that the WBP-2 binding protein, YAP1 enhances PR and ER transactivation but YAP1 s coactivation function is absolutely dependent on WBP-2. Furthermore, cPPXY motif of WBP-2 and WW-domain of YAP1 is required for YAP1 to work as a transcriptional coactiva-tor. Additionally, our data also indicate that the coactivation functions of WBP-2 and YAP1 are suppressed by WWOX1, suggesting that WWOX1 may regulates the transactivation functions of ER and PR by antagonizing the functions of WBP-2 and YAP1. Taken together our data estab-lished the role of WBP-2 and YAP1 as coactivators and WWOX1 as a repressor for ER and PR transactivation pathways." @default.
• W1499053463 created "2016-06-24" @default.
• W1499053463 creator A5010151240 @default.
• W1499053463 creator A5075879128 @default.
• W1499053463 date "2007-03-01" @default.
• W1499053463 modified "2023-10-17" @default.
• W1499053463 title "Role of the PY Motif Containing Protein, WBP-2 in ER, PR Signaling and Breast Tumorigenesis" @default.
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