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- W14992114 abstract "It has been reported that small intestinal transit (SIT) in the rat is not cholinergically mediated. The geometric mean of a marker may be a more powerful method for SIT studies. Therefore, it was their goal to evaluate the effect of muscarinic blockade in normal and prostaglandin E/sub 2/ (PGE/sub 2/)-enhanced SIT using this method. Male, food-fasted rats (190 to 240 g) were first dosed subcutaneously with atropine. 30 min after the atropine the rats received an oral dose of PGE/sub 2/ at 5.0 mg/kg. 5 min after PGE/sub 2/, a /sup 51/Cr-labeled marker was dosed intraduodenally, and a 25 min transit period followed. The results are: (1) 5.0 mg/kg of PGE/sub 2/ significantly stimulates the geometric mean of the marker in agreement with previous findings and (2) atropine is inhibitory at doses as low as 0.20 mg/kg for basal SIT and 0.10 mg/kg for PGE/sub 2/-stimulated SIT. This indicates (1) the rat has cholinergically mediated SIT, and (2) cholinergic activation may be important for PGE/sub 2/ effects on SIT in the rat." @default.
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- W14992114 date "1986-03-05" @default.
- W14992114 modified "2023-10-15" @default.
- W14992114 title "Cholinergic mediation of small intestinal transit in the rat" @default.
- W14992114 hasPublicationYear "1986" @default.
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