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- W1499371148 abstract "Abstract Merkel cells (MCs) are specialized sensory cells widely distributed in the epithclia of vertebrates. A variable immunohistochemical pattern of neuronal and neurotransmitter markers has been demonstrated in MCs of several species including man. In the present study, we investigated the expression of neurochemical markers in a selected population of human cutaneous MCs by immunofluorescence. The structural neural proteins protein gene product 9.5 and neuron-specific enolase were found to be the most reliable markers for MC identification. Moreover, neurofil-ament immunoreactivity was shown in a small subset of epidermal MCs. Among the neurotransmitter markers, evidence for expression of calcitonin gene-related peptide, vasoactive intestinal polypeptide, peptide histidine isoleucine amide, neuropeptide Y, neurokinin A, galanin, substance P, som-atostatin and phenylethanolamine N-methyltransferase was found. These immunoreactivities were highly variable as far as number of positive cells and staining intensity were concerned. The results indicate that a complex and heterogenous immunophenotype can be expressed even within a homogeneous population of human MCs." @default.
- W1499371148 created "2016-06-24" @default.
- W1499371148 creator A5016399484 @default.
- W1499371148 creator A5069912409 @default.
- W1499371148 date "1995-12-01" @default.
- W1499371148 modified "2023-10-13" @default.
- W1499371148 title "Neurochemical markers in human cutaneous Merkel cells. An immunohistochemical investigation" @default.
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- W1499371148 doi "https://doi.org/10.1111/j.1600-0625.1995.tb00061.x" @default.
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