Matches in SemOpenAlex for { <https://semopenalex.org/work/W1499425110> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1499425110 abstract "Alzheimer's disease is an incurable illness. It affects about half a million people in Russia, and due to the general trend towards aging of the population the number of Alzheimer's disease cases will steadily increase. Insoluble deposits of amyloid beta in the brain tissue (amyloid plaques) are the major morphological characteristic of Alzheimer's disease. It has been found that the increased concentration of copper in amyloid plaques results in copper ions bound to the protein. It is the presence of copper in the binding site triggers of the formation of amyloid plaques. Therefore, the study of the binding site in amyloid beta is of great scientific interest. The local atomic structure of the Cu(I) copper ion binding site in the amyloid beta peptide has been studied by means of XANES spectroscopy. Several model structures obtained by molecular mechanics and density functional theory (ADF code) have been tested. Theoretical analysis of X-ray absorption spectra based on the finite difference method implemented in FDMNES code was performed. An appropriate model structure of the Cu(I) copper ion binding site in amyloid beta peptide has been found." @default.
- W1499425110 created "2016-06-24" @default.
- W1499425110 creator A5000778001 @default.
- W1499425110 creator A5002197889 @default.
- W1499425110 creator A5016496342 @default.
- W1499425110 creator A5025481493 @default.
- W1499425110 creator A5041768941 @default.
- W1499425110 creator A5072067776 @default.
- W1499425110 creator A5074098435 @default.
- W1499425110 date "2013-02-12" @default.
- W1499425110 modified "2023-09-24" @default.
- W1499425110 title "Рентгеноспектральное исследование и компьютерное моделирование локальной атомной структуры центра связывания иона меди в бета амилоиде" @default.
- W1499425110 cites W1992086733 @default.
- W1499425110 cites W2001221518 @default.
- W1499425110 cites W2043732645 @default.
- W1499425110 cites W2082022687 @default.
- W1499425110 cites W2082027220 @default.
- W1499425110 cites W2150345533 @default.
- W1499425110 cites W2164326789 @default.
- W1499425110 hasPublicationYear "2013" @default.
- W1499425110 type Work @default.
- W1499425110 sameAs 1499425110 @default.
- W1499425110 citedByCount "0" @default.
- W1499425110 crossrefType "journal-article" @default.
- W1499425110 hasAuthorship W1499425110A5000778001 @default.
- W1499425110 hasAuthorship W1499425110A5002197889 @default.
- W1499425110 hasAuthorship W1499425110A5016496342 @default.
- W1499425110 hasAuthorship W1499425110A5025481493 @default.
- W1499425110 hasAuthorship W1499425110A5041768941 @default.
- W1499425110 hasAuthorship W1499425110A5072067776 @default.
- W1499425110 hasAuthorship W1499425110A5074098435 @default.
- W1499425110 hasConcept C107824862 @default.
- W1499425110 hasConcept C12554922 @default.
- W1499425110 hasConcept C142724271 @default.
- W1499425110 hasConcept C177907266 @default.
- W1499425110 hasConcept C178790620 @default.
- W1499425110 hasConcept C179104552 @default.
- W1499425110 hasConcept C185592680 @default.
- W1499425110 hasConcept C199360897 @default.
- W1499425110 hasConcept C2776174256 @default.
- W1499425110 hasConcept C2777633098 @default.
- W1499425110 hasConcept C2779134260 @default.
- W1499425110 hasConcept C2779281246 @default.
- W1499425110 hasConcept C2908647359 @default.
- W1499425110 hasConcept C31705614 @default.
- W1499425110 hasConcept C41008148 @default.
- W1499425110 hasConcept C502032728 @default.
- W1499425110 hasConcept C544778455 @default.
- W1499425110 hasConcept C55493867 @default.
- W1499425110 hasConcept C71924100 @default.
- W1499425110 hasConcept C8010536 @default.
- W1499425110 hasConcept C86803240 @default.
- W1499425110 hasConcept C99454951 @default.
- W1499425110 hasConceptScore W1499425110C107824862 @default.
- W1499425110 hasConceptScore W1499425110C12554922 @default.
- W1499425110 hasConceptScore W1499425110C142724271 @default.
- W1499425110 hasConceptScore W1499425110C177907266 @default.
- W1499425110 hasConceptScore W1499425110C178790620 @default.
- W1499425110 hasConceptScore W1499425110C179104552 @default.
- W1499425110 hasConceptScore W1499425110C185592680 @default.
- W1499425110 hasConceptScore W1499425110C199360897 @default.
- W1499425110 hasConceptScore W1499425110C2776174256 @default.
- W1499425110 hasConceptScore W1499425110C2777633098 @default.
- W1499425110 hasConceptScore W1499425110C2779134260 @default.
- W1499425110 hasConceptScore W1499425110C2779281246 @default.
- W1499425110 hasConceptScore W1499425110C2908647359 @default.
- W1499425110 hasConceptScore W1499425110C31705614 @default.
- W1499425110 hasConceptScore W1499425110C41008148 @default.
- W1499425110 hasConceptScore W1499425110C502032728 @default.
- W1499425110 hasConceptScore W1499425110C544778455 @default.
- W1499425110 hasConceptScore W1499425110C55493867 @default.
- W1499425110 hasConceptScore W1499425110C71924100 @default.
- W1499425110 hasConceptScore W1499425110C8010536 @default.
- W1499425110 hasConceptScore W1499425110C86803240 @default.
- W1499425110 hasConceptScore W1499425110C99454951 @default.
- W1499425110 hasLocation W14994251101 @default.
- W1499425110 hasOpenAccess W1499425110 @default.
- W1499425110 hasPrimaryLocation W14994251101 @default.
- W1499425110 hasVolume "25" @default.
- W1499425110 isParatext "false" @default.
- W1499425110 isRetracted "false" @default.
- W1499425110 magId "1499425110" @default.
- W1499425110 workType "article" @default.