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• W1499476928 abstract "Oestradiol (E2) exerts potent feedback actions upon gonadotrophin-releasing hormone (GnRH) neurones and part of this feedback action may occur through the rapid action of E2. Using a transgenic GnRH-Pericam mouse line that allows real-time intracellular calcium concentrations ([Ca2+]i) to be monitored in adult GnRH neurones in a brain slice preparation, we examined the acute effects of 100 pm–100 nm E2 on [Ca2+]i transients in spontaneously active GnRH neurones. Approximately 30% of GnRH neurones exhibit spontaneous [Ca2+]i transients at a frequency greater than two transients/15 min in adult female mice. In these cells, treatment with an incremental 1, 10, 100 nm E2 protocol or 100 pm E2 alone resulted in the suppression or complete cessation of [Ca2+]i transients in 15 of 18 (83%) GnRH neurones. This effect was mimicked by E2 bound to albumin, suggesting a membrane site of action, and was maintained in oestrogen receptor β knockout mice, indicating that this receptor is not essential for the rapid suppression of [Ca2+]i transients. These findings contrast with those GnRH neurones exhibiting very few or no [Ca2+]i transients (< 2 transients/15 min) that exhibit the opposite response of being activated by acute E2. A series of dual calcium-cell-attached electrical recordings showed that [Ca2+]i transients were associated with GnRH neurone burst firing and that E2 suppression or activation of [Ca2+]i transients was mirrored by a depression or initiation of burst firing. Taken together, these studies demonstrate that the acute actions of E2 on GnRH neurones are critically dependent upon their pattern of burst firing." @default.
• W1499476928 created "2016-06-24" @default.
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• W1499476928 date "2012-09-14" @default.
• W1499476928 modified "2023-10-02" @default.
• W1499476928 title "Activity-Dependent Modulation of Gonadotrophin-Releasing Hormone Neurone Activity by Acute Oestradiol" @default.
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• W1499476928 doi "https://doi.org/10.1111/j.1365-2826.2012.02342.x" @default.
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