Matches in SemOpenAlex for { <https://semopenalex.org/work/W1499492788> ?p ?o ?g. }
- W1499492788 endingPage "685" @default.
- W1499492788 startingPage "677" @default.
- W1499492788 abstract "Abstract The Fas ligand (FasL)/Fas receptor (CD95) pathway is an important mediator of apoptosis in the immune system and can also mediate cancer cell death. Soluble FasL (sFasL), shed from the membrane-bound form of the molecule by a putative metalloproteinase (MP), may function to locally regulate the activity of membrane-bound FasL. Using a replication-defective recombinant adenovirus-expressing FasL (RAdFasL), we identified a variable ability of different carcinoma cells to respond to FasL-induced cytotoxicity and to shed sFasL. Blockade of FasL cleavage with an MP inhibitor significantly enhanced RAdFasL-induced apoptosis suggesting that sFasL may antagonize the effect of membrane-bound FasL. In support of this concept, a recombinant adenovirus expressing a noncleavable form of FasL (RAdD4) was found to be a potent inducer of apoptosis even at very low virus doses. Our results highlight the therapeutic potential of noncleavable FasL as an antitumor agent and emphasize the important role of MP via the production of sFasL in regulating the response of the Fas pathway. Moreover, these findings have general implications for the therapeutic exploitation of TNF family ligands and for the possible impact of MP-based therapies on the normal physiology of Fas/TNF pathways." @default.
- W1499492788 created "2016-06-24" @default.
- W1499492788 creator A5009080881 @default.
- W1499492788 creator A5057196333 @default.
- W1499492788 creator A5067846568 @default.
- W1499492788 creator A5069002684 @default.
- W1499492788 creator A5071694950 @default.
- W1499492788 date "2003-01-15" @default.
- W1499492788 modified "2023-09-29" @default.
- W1499492788 title "Inhibition of Metalloproteinase Cleavage Enhances the Cytotoxicity of Fas Ligand" @default.
- W1499492788 cites W1480949286 @default.
- W1499492788 cites W1514099677 @default.
- W1499492788 cites W1517945724 @default.
- W1499492788 cites W1561515054 @default.
- W1499492788 cites W1642763135 @default.
- W1499492788 cites W1662819364 @default.
- W1499492788 cites W1671694443 @default.
- W1499492788 cites W1672465829 @default.
- W1499492788 cites W1973792489 @default.
- W1499492788 cites W1975291295 @default.
- W1499492788 cites W1977499961 @default.
- W1499492788 cites W1978018492 @default.
- W1499492788 cites W1978480779 @default.
- W1499492788 cites W1989600187 @default.
- W1499492788 cites W1992060545 @default.
- W1499492788 cites W1992386229 @default.
- W1499492788 cites W1994696929 @default.
- W1499492788 cites W1996174406 @default.
- W1499492788 cites W1996980134 @default.
- W1499492788 cites W1997296950 @default.
- W1499492788 cites W2002143278 @default.
- W1499492788 cites W2002733542 @default.
- W1499492788 cites W2003403133 @default.
- W1499492788 cites W2004645606 @default.
- W1499492788 cites W2004823364 @default.
- W1499492788 cites W2011660637 @default.
- W1499492788 cites W2023040267 @default.
- W1499492788 cites W2036842448 @default.
- W1499492788 cites W2037804577 @default.
- W1499492788 cites W2045068005 @default.
- W1499492788 cites W2047468407 @default.
- W1499492788 cites W2052398986 @default.
- W1499492788 cites W2067142683 @default.
- W1499492788 cites W2074562878 @default.
- W1499492788 cites W2074881372 @default.
- W1499492788 cites W2075809552 @default.
- W1499492788 cites W2076229621 @default.
- W1499492788 cites W2078901980 @default.
- W1499492788 cites W2086313080 @default.
- W1499492788 cites W2096950793 @default.
- W1499492788 cites W2097499121 @default.
- W1499492788 cites W2098593116 @default.
- W1499492788 cites W2110900696 @default.
- W1499492788 cites W2114918609 @default.
- W1499492788 cites W2116958667 @default.
- W1499492788 cites W2121500468 @default.
- W1499492788 cites W2139827960 @default.
- W1499492788 cites W2139983785 @default.
- W1499492788 cites W2143304082 @default.
- W1499492788 cites W2143996326 @default.
- W1499492788 cites W2152754469 @default.
- W1499492788 cites W2164802863 @default.
- W1499492788 cites W2168945225 @default.
- W1499492788 cites W2318257908 @default.
- W1499492788 cites W2322876587 @default.
- W1499492788 cites W4236961483 @default.
- W1499492788 doi "https://doi.org/10.4049/jimmunol.170.2.677" @default.
- W1499492788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12517928" @default.
- W1499492788 hasPublicationYear "2003" @default.
- W1499492788 type Work @default.
- W1499492788 sameAs 1499492788 @default.
- W1499492788 citedByCount "53" @default.
- W1499492788 countsByYear W14994927882012 @default.
- W1499492788 countsByYear W14994927882013 @default.
- W1499492788 countsByYear W14994927882014 @default.
- W1499492788 countsByYear W14994927882016 @default.
- W1499492788 countsByYear W14994927882017 @default.
- W1499492788 countsByYear W14994927882019 @default.
- W1499492788 countsByYear W14994927882020 @default.
- W1499492788 countsByYear W14994927882022 @default.
- W1499492788 crossrefType "journal-article" @default.
- W1499492788 hasAuthorship W1499492788A5009080881 @default.
- W1499492788 hasAuthorship W1499492788A5057196333 @default.
- W1499492788 hasAuthorship W1499492788A5067846568 @default.
- W1499492788 hasAuthorship W1499492788A5069002684 @default.
- W1499492788 hasAuthorship W1499492788A5071694950 @default.
- W1499492788 hasBestOaLocation W14994927881 @default.
- W1499492788 hasConcept C109316439 @default.
- W1499492788 hasConcept C170493617 @default.
- W1499492788 hasConcept C17991360 @default.
- W1499492788 hasConcept C185592680 @default.
- W1499492788 hasConcept C190283241 @default.
- W1499492788 hasConcept C202751555 @default.
- W1499492788 hasConcept C203014093 @default.
- W1499492788 hasConcept C3031857 @default.
- W1499492788 hasConcept C31573885 @default.
- W1499492788 hasConcept C502942594 @default.
- W1499492788 hasConcept C55493867 @default.