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- W1499571879 abstract "Objective: To investigate relationships between body mass index (BMI) and mortality in diabetes where obesity has been paradoxically associated with lower mortality risk than normal weight and to examine the possible role of muscle, adiposity and function. Design: Participants aged 66-96 years with diabetes from self-report, medication or fasting glucose 蠅7mmol/l in the AGES-Reykjavik Study. BMI was classified as normal weight (18.5-24.9kg/m2, N=114) or overweight/obese (蠅25.0kg/m2, N=520). Thigh muscle area, abdominal and thigh adipose depots were assessed with computed tomography. Function was assessed from gait speed and leg strength. Outcome: Mortality risk (hazard ratios (HR) and 95% confidence intervals (CI)) over a mean of 6.5 years were assessed by Cox models, reference category overweight/obese. Results: In adjusted models (demographics, diabetes duration, medications, blood pressure, lipids, waist circumference, mid-life BMI, smoking, microalbuminuria, inflammation and hypertension), normal weight participants had higher mortality risk (HR 1.69 95% CI 1.10-2.61) than overweight/obese participants. Risk remained with adjustment for adipose depots and strength but was attenuated with adjustment for muscle area (HR 1.33 95% CI 0.86-2.06) and gait speed (HR 1.54, 95% CI 0.97-2.43). Conclusion: Muscle size and function may help explain the obesity paradox among adults with diabetes. Grant Funding Source: Supported by NIH contract N01-AG012100, the NIA Intramural Research Program, Hjartavernd (the Icelan" @default.
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- W1499571879 date "2014-04-01" @default.
- W1499571879 modified "2023-10-16" @default.
- W1499571879 title "New insight into the obesity paradox among older adults with diabetes (391.7)" @default.
- W1499571879 doi "https://doi.org/10.1096/fasebj.28.1_supplement.391.7" @default.
- W1499571879 hasPublicationYear "2014" @default.
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