Matches in SemOpenAlex for { <https://semopenalex.org/work/W1499572511> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1499572511 endingPage "1859" @default.
- W1499572511 startingPage "1853" @default.
- W1499572511 abstract "ABSTRACT Simian-human immunodeficiency virus (SHIV) infection in macaques provides a convenient model for testing vaccine efficacy and for understanding viral pathogenesis in AIDS. We immunized macaques with recombinant, Salmonella typhimurium (expressing Gag) or soluble Gag in adjuvant to generate T-cell-dependent lymphoproliferative or serum antibody responses. Immunized animals were challenged by intrarectal inoculation with SHIV89.6PD. Virus infection was accompanied by rapid losses of lymphoproliferative responses to Gag or phytohemagglutinin. By 8 weeks, mitogen responses recovered to near normal levels but antigen-specific immunity remained at low or undetectable levels. Serum antibody levels were elevated initially by virus exposure but soon dropped well below levels achieved by immunization. Our studies show a rapid depletion of preexisting Gag-specific CD4 + T cells that prevent or limit subsequent antiviral cellular and humoral immune responses during acute SHIV infection." @default.
- W1499572511 created "2016-06-24" @default.
- W1499572511 creator A5024668426 @default.
- W1499572511 creator A5030389060 @default.
- W1499572511 creator A5060929582 @default.
- W1499572511 date "1999-03-01" @default.
- W1499572511 modified "2023-10-16" @default.
- W1499572511 title "Acute Effects of Pathogenic Simian-Human Immunodeficiency Virus Challenge on Vaccine-Induced Cellular and Humoral Immune Responses to Gag in Rhesus Macaques" @default.
- W1499572511 cites W1586476245 @default.
- W1499572511 cites W1753511464 @default.
- W1499572511 cites W1837018648 @default.
- W1499572511 cites W2003957629 @default.
- W1499572511 cites W2013998395 @default.
- W1499572511 cites W2015638154 @default.
- W1499572511 cites W2015693740 @default.
- W1499572511 cites W2030412750 @default.
- W1499572511 cites W2037343680 @default.
- W1499572511 cites W2044737700 @default.
- W1499572511 cites W2068522864 @default.
- W1499572511 cites W2097623691 @default.
- W1499572511 cites W2100961795 @default.
- W1499572511 cites W2111704944 @default.
- W1499572511 cites W2168146552 @default.
- W1499572511 cites W2168356415 @default.
- W1499572511 cites W2323911477 @default.
- W1499572511 cites W2412053990 @default.
- W1499572511 doi "https://doi.org/10.1128/jvi.73.3.1853-1859.1999" @default.
- W1499572511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/104425" @default.
- W1499572511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9971763" @default.
- W1499572511 hasPublicationYear "1999" @default.
- W1499572511 type Work @default.
- W1499572511 sameAs 1499572511 @default.
- W1499572511 citedByCount "19" @default.
- W1499572511 countsByYear W14995725112021 @default.
- W1499572511 crossrefType "journal-article" @default.
- W1499572511 hasAuthorship W1499572511A5024668426 @default.
- W1499572511 hasAuthorship W1499572511A5030389060 @default.
- W1499572511 hasAuthorship W1499572511A5060929582 @default.
- W1499572511 hasBestOaLocation W14995725111 @default.
- W1499572511 hasConcept C137061746 @default.
- W1499572511 hasConcept C147483822 @default.
- W1499572511 hasConcept C159047783 @default.
- W1499572511 hasConcept C159654299 @default.
- W1499572511 hasConcept C202751555 @default.
- W1499572511 hasConcept C203014093 @default.
- W1499572511 hasConcept C2522874641 @default.
- W1499572511 hasConcept C2776488936 @default.
- W1499572511 hasConcept C2776548049 @default.
- W1499572511 hasConcept C2776969849 @default.
- W1499572511 hasConcept C2777607303 @default.
- W1499572511 hasConcept C2777863537 @default.
- W1499572511 hasConcept C2777995582 @default.
- W1499572511 hasConcept C2779341262 @default.
- W1499572511 hasConcept C3017875465 @default.
- W1499572511 hasConcept C55493867 @default.
- W1499572511 hasConcept C86803240 @default.
- W1499572511 hasConcept C8891405 @default.
- W1499572511 hasConceptScore W1499572511C137061746 @default.
- W1499572511 hasConceptScore W1499572511C147483822 @default.
- W1499572511 hasConceptScore W1499572511C159047783 @default.
- W1499572511 hasConceptScore W1499572511C159654299 @default.
- W1499572511 hasConceptScore W1499572511C202751555 @default.
- W1499572511 hasConceptScore W1499572511C203014093 @default.
- W1499572511 hasConceptScore W1499572511C2522874641 @default.
- W1499572511 hasConceptScore W1499572511C2776488936 @default.
- W1499572511 hasConceptScore W1499572511C2776548049 @default.
- W1499572511 hasConceptScore W1499572511C2776969849 @default.
- W1499572511 hasConceptScore W1499572511C2777607303 @default.
- W1499572511 hasConceptScore W1499572511C2777863537 @default.
- W1499572511 hasConceptScore W1499572511C2777995582 @default.
- W1499572511 hasConceptScore W1499572511C2779341262 @default.
- W1499572511 hasConceptScore W1499572511C3017875465 @default.
- W1499572511 hasConceptScore W1499572511C55493867 @default.
- W1499572511 hasConceptScore W1499572511C86803240 @default.
- W1499572511 hasConceptScore W1499572511C8891405 @default.
- W1499572511 hasIssue "3" @default.
- W1499572511 hasLocation W14995725111 @default.
- W1499572511 hasLocation W14995725112 @default.
- W1499572511 hasLocation W14995725113 @default.
- W1499572511 hasOpenAccess W1499572511 @default.
- W1499572511 hasPrimaryLocation W14995725111 @default.
- W1499572511 hasRelatedWork W1489355333 @default.
- W1499572511 hasRelatedWork W1604914713 @default.
- W1499572511 hasRelatedWork W2013084060 @default.
- W1499572511 hasRelatedWork W2041187342 @default.
- W1499572511 hasRelatedWork W205653339 @default.
- W1499572511 hasRelatedWork W2161164629 @default.
- W1499572511 hasRelatedWork W2414812568 @default.
- W1499572511 hasRelatedWork W2462663805 @default.
- W1499572511 hasRelatedWork W2521551508 @default.
- W1499572511 hasRelatedWork W3215429818 @default.
- W1499572511 hasVolume "73" @default.
- W1499572511 isParatext "false" @default.
- W1499572511 isRetracted "false" @default.
- W1499572511 magId "1499572511" @default.
- W1499572511 workType "article" @default.