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• W1499632014 abstract "A gene that directs the programmed synthesis of flagellar beta-tubulin during the rapid differentiation of Naegleria gruberi from amoebae to flagellates has been cloned and sequenced. The intronless gene is one of 8 to 10 similar but non-identical genes that are dispersed in the genome. beta-Tubulin mRNA homologous to this gene family is expressed transiently during differentiation, and has not been detected in amoebae. The encoded beta-tubulin is strongly conserved, with features that closely resemble the beta-tubulins of diverse organisms, especially organisms that, like Naegleria, use tubulin to assemble flagellar axonemes. In most sequenced alpha-tubulins, the encoded carboxy-terminal amino acid is tyrosine, which undergoes post-translational removal and readdition, conserved processes of unknown function. In N. gruberi, unusually, the terminus of alpha-tubulin is encoded as glutamine while that of beta-tubulin is tyrosine. The presence of these divergent termini on subunits of a conserved tubulin provoked us to re-examine aromatic amino acids at the termini of alpha- and beta-tubulins. Although evolution has tinkered extensively with the carboxy-terminal domains of tubulin subunits, we find an unexpected conservation. In every organism or cell type for which both tubulin subunits have been sequenced, except the ciliate Stylonychia lemnae, at least one tubulin subunit of some or all tubulin heterodimers terminates in an aromatic amino acid, either tyrosine or phenylalanine. This remarkable conservation of carboxy-terminal aromatic amino acids suggests that these residues serve some crucial function." @default.
• W1499632014 created "2016-06-24" @default.
• W1499632014 creator A5030180240 @default.
• W1499632014 creator A5040554812 @default.
• W1499632014 creator A5069537006 @default.
• W1499632014 date "1994-01-01" @default.
• W1499632014 modified "2023-09-23" @default.
• W1499632014 title "A β-tubulin gene of Naegleria encodes a carboxy-terminal tyrosine" @default.
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• W1499632014 doi "https://doi.org/10.1016/s0022-2836(05)80045-2" @default.
• W1499632014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8289261" @default.
• W1499632014 hasPublicationYear "1994" @default.
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