Matches in SemOpenAlex for { <https://semopenalex.org/work/W1499681948> ?p ?o ?g. }
- W1499681948 abstract "Publisher Summary The chapter focuses on the characterization of Ca 2+ signals evoked by extracellular purine and pyrimidine nucleotides in astrocytes from the spinal cord. The chapter demonstrates that spinal cord astrocytes express two functionally distinct subtypes of nucleotide receptor. One receptor appears to be the cloned P2Y 1 receptor while the other represents a novel P2Y receptor subtype activated by uridine- 5 '-triphosphate (UTP). Each receptor couples to the release of Ca 2+ from IP 3 -sensitive intracellular stores but when subjected to sustained stimulation the two subtypes of receptor induce distinctive Ca 2+ response patterns. The chapter reveals that the differing Ca 2+ signals evoked by the different receptors may have distinct functional consequences in terms of signal discrimination, gene expression, growth, and proliferation. The morphological changes induced by ATP stimulation of astrocytes require prolonged periods of stimulation. Thus, in terms of possible involvement of the two metabotropic P2 receptors, involvement of the P2Y receptor seems unlikely as the Ca 2+ signal evoked by stimulating this receptor subtype fades rapidly with sustained stimulation. On the other hand, the pyrimidinoceptor-triggered Ca 2+ signal persists during the prolonged elevations of extracellular nucleotide." @default.
- W1499681948 created "2016-06-24" @default.
- W1499681948 creator A5010218872 @default.
- W1499681948 creator A5079156379 @default.
- W1499681948 date "1999-01-01" @default.
- W1499681948 modified "2023-09-26" @default.
- W1499681948 title "Chapter 25 Nucleotide receptor signalling in spinal cord astrocytes: Findings and functional implications" @default.
- W1499681948 cites W1024952871 @default.
- W1499681948 cites W1500488100 @default.
- W1499681948 cites W1532560676 @default.
- W1499681948 cites W1542171240 @default.
- W1499681948 cites W1593385535 @default.
- W1499681948 cites W1629086159 @default.
- W1499681948 cites W1642980781 @default.
- W1499681948 cites W1650401181 @default.
- W1499681948 cites W1914852136 @default.
- W1499681948 cites W1947888345 @default.
- W1499681948 cites W1965484171 @default.
- W1499681948 cites W1974260260 @default.
- W1499681948 cites W1976142920 @default.
- W1499681948 cites W1980166477 @default.
- W1499681948 cites W1981182586 @default.
- W1499681948 cites W1982553763 @default.
- W1499681948 cites W1992600646 @default.
- W1499681948 cites W1993579552 @default.
- W1499681948 cites W1994109113 @default.
- W1499681948 cites W1996603253 @default.
- W1499681948 cites W1997118739 @default.
- W1499681948 cites W2001789263 @default.
- W1499681948 cites W2003102216 @default.
- W1499681948 cites W2003819256 @default.
- W1499681948 cites W2005124478 @default.
- W1499681948 cites W2006207066 @default.
- W1499681948 cites W2007910408 @default.
- W1499681948 cites W2013443391 @default.
- W1499681948 cites W2014543453 @default.
- W1499681948 cites W2017523469 @default.
- W1499681948 cites W2027126767 @default.
- W1499681948 cites W2027205116 @default.
- W1499681948 cites W2027685264 @default.
- W1499681948 cites W2028684902 @default.
- W1499681948 cites W2038622543 @default.
- W1499681948 cites W2041690080 @default.
- W1499681948 cites W2044581359 @default.
- W1499681948 cites W2046470965 @default.
- W1499681948 cites W2050074458 @default.
- W1499681948 cites W2050338155 @default.
- W1499681948 cites W2051877077 @default.
- W1499681948 cites W2052530663 @default.
- W1499681948 cites W2052854972 @default.
- W1499681948 cites W2056358535 @default.
- W1499681948 cites W2057216006 @default.
- W1499681948 cites W2063551274 @default.
- W1499681948 cites W2064647534 @default.
- W1499681948 cites W2065843356 @default.
- W1499681948 cites W2071184494 @default.
- W1499681948 cites W2075760418 @default.
- W1499681948 cites W2087667366 @default.
- W1499681948 cites W2087888155 @default.
- W1499681948 cites W2090253465 @default.
- W1499681948 cites W2094412950 @default.
- W1499681948 cites W2104529835 @default.
- W1499681948 cites W2109311512 @default.
- W1499681948 cites W2115972383 @default.
- W1499681948 cites W2120613443 @default.
- W1499681948 cites W2130503561 @default.
- W1499681948 cites W2132998193 @default.
- W1499681948 cites W2141892357 @default.
- W1499681948 cites W2158972964 @default.
- W1499681948 cites W2170854858 @default.
- W1499681948 cites W2342357931 @default.
- W1499681948 cites W2890372342 @default.
- W1499681948 cites W572417620 @default.
- W1499681948 cites W2088729275 @default.
- W1499681948 doi "https://doi.org/10.1016/s0079-6123(08)63565-7" @default.
- W1499681948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10551007" @default.
- W1499681948 hasPublicationYear "1999" @default.
- W1499681948 type Work @default.
- W1499681948 sameAs 1499681948 @default.
- W1499681948 citedByCount "5" @default.
- W1499681948 crossrefType "book-chapter" @default.
- W1499681948 hasAuthorship W1499681948A5010218872 @default.
- W1499681948 hasAuthorship W1499681948A5079156379 @default.
- W1499681948 hasConcept C160225129 @default.
- W1499681948 hasConcept C169760540 @default.
- W1499681948 hasConcept C170493617 @default.
- W1499681948 hasConcept C24998067 @default.
- W1499681948 hasConcept C26702167 @default.
- W1499681948 hasConcept C2780410667 @default.
- W1499681948 hasConcept C28406088 @default.
- W1499681948 hasConcept C55493867 @default.
- W1499681948 hasConcept C57306754 @default.
- W1499681948 hasConcept C61174792 @default.
- W1499681948 hasConcept C62478195 @default.
- W1499681948 hasConcept C86803240 @default.
- W1499681948 hasConcept C95444343 @default.
- W1499681948 hasConceptScore W1499681948C160225129 @default.
- W1499681948 hasConceptScore W1499681948C169760540 @default.
- W1499681948 hasConceptScore W1499681948C170493617 @default.
- W1499681948 hasConceptScore W1499681948C24998067 @default.