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- W1499693561 abstract "Many studies, using a wide range of techniques, have indicated that the central noradrenergic system of rats is extremely sensitive to non-noxious, but aversive environmental stimuli. The effects of stress experienced in early life (social isolation) are particularly interesting because the ensuing changes in the central noradrenergic system seem to be relevant to the causes of psychiatric disorders in humans that are exacerbated by stress (e.g. depression and schizophrenia). However, noradrenergic neurones projecting to different regions of the brain make different contributions to the response and adaptation to stress. This is especially apparent when comparing the noradrenergic response to conditioned and unconditioned environmental stimuli. Finally, evidence from studies of inbred rat strains points to differences in noradrenergic transmission, which influence the stress response and behaviour, that are determined by genotype. This chapter draws on evidence from all these experimental approaches and discusses the proposal that noradrenergic transmission makes an important contribution to coping with mild stress but that, when the stress is intense, it exacerbates the impact of the stressor on mood and behaviour." @default.
- W1499693561 created "2016-06-24" @default.
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- W1499693561 date "2005-01-01" @default.
- W1499693561 modified "2023-10-18" @default.
- W1499693561 title "Regional specialisation in the central noradrenergic response to unconditioned and conditioned environmental stimuli" @default.
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- W1499693561 doi "https://doi.org/10.1016/s0921-0709(05)80027-6" @default.
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