FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1499817490> ?p ?o ?g. }

• W1499817490 endingPage "550" @default.
• W1499817490 startingPage "543" @default.
• W1499817490 abstract "Experimental studies and theoretical considerations have shown that only a small subset of Escherichia coli proteins fold in vivo with the help of the GroE chaperone system. These proteins, termed GroE substrates, have been divided into three classes: (a) proteins that can fold independently, but are found to associate with GroEL; (b) proteins that require GroE when the cell is under stress; and (c) 'obligatory' proteins that require GroE assistance even under normal conditions. It remains unclear, however, why some proteins need GroE and others do not. Here, we review experimental and computational studies that addressed this question by comparing the sequences and structural, biophysical and evolutionary properties of GroE substrates with those of nonsubstrates. In general, obligatory substrates are found to have lower folding propensities and be more aggregation prone. GroE substrates are also more conserved than other proteins and tend to utilize more optimal codons, but this latter feature is less apparent for obligatory substrates. There is no evidence, however, for any specific sequence signatures although there is a tendency for sequence periodicity. Our review shows that reliable sequence- or structure-based predictions of GroE dependency remain a challenge. We suggest that the different classes of GroE substrates be studied separately and that proper control test sets (e.g. TIM barrel proteins that need GroE for folding versus TIM barrels that fold independently) be used more extensively in such studies." @default.
• W1499817490 created "2016-06-24" @default.
• W1499817490 creator A5014486140 @default.
• W1499817490 creator A5045097532 @default.
• W1499817490 creator A5056692823 @default.
• W1499817490 date "2012-01-04" @default.
• W1499817490 modified "2023-10-09" @default.
• W1499817490 title "What distinguishes GroEL substrates from other Escherichia coli proteins?" @default.
• W1499817490 cites W1533808701 @default.
• W1499817490 cites W1556287360 @default.
• W1499817490 cites W1627863859 @default.
• W1499817490 cites W1957954827 @default.
• W1499817490 cites W1985818354 @default.
• W1499817490 cites W1990403227 @default.
• W1499817490 cites W2004674004 @default.
• W1499817490 cites W2005341355 @default.
• W1499817490 cites W2009645251 @default.
• W1499817490 cites W2012268867 @default.
• W1499817490 cites W2021242983 @default.
• W1499817490 cites W2029086579 @default.
• W1499817490 cites W2030347831 @default.
• W1499817490 cites W2031141619 @default.
• W1499817490 cites W2037598833 @default.
• W1499817490 cites W2039790548 @default.
• W1499817490 cites W2043825438 @default.
• W1499817490 cites W2059017497 @default.
• W1499817490 cites W2076250087 @default.
• W1499817490 cites W2078010704 @default.
• W1499817490 cites W2100408989 @default.
• W1499817490 cites W2101457557 @default.
• W1499817490 cites W2101520669 @default.
• W1499817490 cites W2103091054 @default.
• W1499817490 cites W2103918159 @default.
• W1499817490 cites W2105463652 @default.
• W1499817490 cites W2117929060 @default.
• W1499817490 cites W2120717592 @default.
• W1499817490 cites W2121963790 @default.
• W1499817490 cites W2128072247 @default.
• W1499817490 cites W2131965976 @default.
• W1499817490 cites W2141809319 @default.
• W1499817490 cites W2147289825 @default.
• W1499817490 cites W2159343255 @default.
• W1499817490 cites W2171533950 @default.
• W1499817490 cites W2172355503 @default.
• W1499817490 doi "https://doi.org/10.1111/j.1742-4658.2011.08458.x" @default.
• W1499817490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22177460" @default.
• W1499817490 hasPublicationYear "2012" @default.
• W1499817490 type Work @default.
• W1499817490 sameAs 1499817490 @default.
• W1499817490 citedByCount "44" @default.
• W1499817490 countsByYear W14998174902012 @default.
• W1499817490 countsByYear W14998174902013 @default.
• W1499817490 countsByYear W14998174902014 @default.
• W1499817490 countsByYear W14998174902015 @default.
• W1499817490 countsByYear W14998174902016 @default.
• W1499817490 countsByYear W14998174902017 @default.
• W1499817490 countsByYear W14998174902018 @default.
• W1499817490 countsByYear W14998174902019 @default.
• W1499817490 countsByYear W14998174902020 @default.
• W1499817490 countsByYear W14998174902021 @default.
• W1499817490 countsByYear W14998174902022 @default.
• W1499817490 countsByYear W14998174902023 @default.
• W1499817490 crossrefType "journal-article" @default.
• W1499817490 hasAuthorship W1499817490A5014486140 @default.
• W1499817490 hasAuthorship W1499817490A5045097532 @default.
• W1499817490 hasAuthorship W1499817490A5056692823 @default.
• W1499817490 hasBestOaLocation W14998174901 @default.
• W1499817490 hasConcept C104317684 @default.
• W1499817490 hasConcept C142724271 @default.
• W1499817490 hasConcept C204328495 @default.
• W1499817490 hasConcept C2775962898 @default.
• W1499817490 hasConcept C54355233 @default.
• W1499817490 hasConcept C547475151 @default.
• W1499817490 hasConcept C55493867 @default.
• W1499817490 hasConcept C70721500 @default.
• W1499817490 hasConcept C71924100 @default.
• W1499817490 hasConcept C85755625 @default.
• W1499817490 hasConcept C86803240 @default.
• W1499817490 hasConcept C87190427 @default.
• W1499817490 hasConceptScore W1499817490C104317684 @default.
• W1499817490 hasConceptScore W1499817490C142724271 @default.
• W1499817490 hasConceptScore W1499817490C204328495 @default.
• W1499817490 hasConceptScore W1499817490C2775962898 @default.
• W1499817490 hasConceptScore W1499817490C54355233 @default.
• W1499817490 hasConceptScore W1499817490C547475151 @default.
• W1499817490 hasConceptScore W1499817490C55493867 @default.
• W1499817490 hasConceptScore W1499817490C70721500 @default.
• W1499817490 hasConceptScore W1499817490C71924100 @default.
• W1499817490 hasConceptScore W1499817490C85755625 @default.
• W1499817490 hasConceptScore W1499817490C86803240 @default.
• W1499817490 hasConceptScore W1499817490C87190427 @default.
• W1499817490 hasIssue "4" @default.
• W1499817490 hasLocation W14998174901 @default.
• W1499817490 hasLocation W14998174902 @default.
• W1499817490 hasOpenAccess W1499817490 @default.
• W1499817490 hasPrimaryLocation W14998174901 @default.
• W1499817490 hasRelatedWork W1552392580 @default.
• W1499817490 hasRelatedWork W1970978994 @default.

• next