FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1499889283> ?p ?o ?g. }

• W1499889283 endingPage "14144" @default.
• W1499889283 startingPage "14137" @default.
• W1499889283 abstract "Hepatocytes obtained from rats fed for 3 days chow (control) or drinking water only (fasted) were used to examine how metabolic state affects lipogenesis, apolipoprotein synthesis, and the capacity to secrete de novo synthesized triacylglycerol. The secretion of triacylglycerol (mass and 3H-labeled via 3H2O incorporation) by both groups of cells was constant for 30 h. Moreover, cells from fasted rats secreted triacylglycerol at rates which were markedly reduced (mass -84%; 3H-labeled -91%). To assess the relative capacities of the two groups of hepatocytes to augment triacylglycerol secretion in response to stimulated lipogenesis, cells were incubated with increasing concentrations of glucose. Control cells responded to glucose by increasing equally the synthesis and secretion of [3H] triacylglycerol. When cells from fasted rats were challenged with glucose, triacylglycerol secretion was not increased. Rather, it accumulated intracellularly. Double-reciprocal plot analysis of the capacity to augment triacylglycerol secretion in response to glucose showed that cells from fasted rats had a greater than 10-fold decrease in V'max. Moreover, fasting changed the synthesis and secretion of apolipoproteins selectively: secretion of low molecular weight apo-B was decreased 50%, large molecular weight apo-B was unchanged, and apo-E was increased 2-4-fold. Analysis of the lipoproteins from both groups of cells on Bio-Gel A-50m showed that the very low density lipoprotein secreted by cells from fasted rats was smaller. In addition, all of the increased de novo synthesized apo-E secreted by cells from fasted rats eluted after the triacylglycerol-rich lipoproteins. The combined data show that: 1) the synthesis of individual very low density lipoprotein apolipoproteins is independently regulated, and 2) the synthesis (availability) of apo-B determines the capacity of the hepatocyte to assemble/secrete triacylglycerol-rich very low density lipoprotein." @default.
• W1499889283 created "2016-06-24" @default.
• W1499889283 creator A5008592361 @default.
• W1499889283 creator A5033012006 @default.
• W1499889283 creator A5069006078 @default.
• W1499889283 creator A5073100780 @default.
• W1499889283 creator A5076771279 @default.
• W1499889283 date "1985-11-01" @default.
• W1499889283 modified "2023-09-28" @default.
• W1499889283 title "Intrahepatic assembly of very low density lipoproteins. Varied synthetic response of individual apolipoproteins to fasting." @default.
• W1499889283 cites W1506096423 @default.
• W1499889283 cites W1506448714 @default.
• W1499889283 cites W1569439639 @default.
• W1499889283 cites W1588895741 @default.
• W1499889283 cites W168008062 @default.
• W1499889283 cites W1775749144 @default.
• W1499889283 cites W1914323296 @default.
• W1499889283 cites W1964558072 @default.
• W1499889283 cites W1974527504 @default.
• W1499889283 cites W1976303136 @default.
• W1499889283 cites W1988220724 @default.
• W1499889283 cites W1993140953 @default.
• W1499889283 cites W1996345715 @default.
• W1499889283 cites W2000908867 @default.
• W1499889283 cites W2002892589 @default.
• W1499889283 cites W2007715864 @default.
• W1499889283 cites W2011230385 @default.
• W1499889283 cites W2017640755 @default.
• W1499889283 cites W2057365575 @default.
• W1499889283 cites W2066438653 @default.
• W1499889283 cites W2080933646 @default.
• W1499889283 cites W2108815329 @default.
• W1499889283 cites W2113006405 @default.
• W1499889283 cites W2124566856 @default.
• W1499889283 cites W2156799866 @default.
• W1499889283 cites W2284644432 @default.
• W1499889283 cites W2312973106 @default.
• W1499889283 doi "https://doi.org/10.1016/s0021-9258(17)38694-5" @default.
• W1499889283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4055774" @default.
• W1499889283 hasPublicationYear "1985" @default.
• W1499889283 type Work @default.
• W1499889283 sameAs 1499889283 @default.
• W1499889283 citedByCount "105" @default.
• W1499889283 countsByYear W14998892832014 @default.
• W1499889283 crossrefType "journal-article" @default.
• W1499889283 hasAuthorship W1499889283A5008592361 @default.
• W1499889283 hasAuthorship W1499889283A5033012006 @default.
• W1499889283 hasAuthorship W1499889283A5069006078 @default.
• W1499889283 hasAuthorship W1499889283A5073100780 @default.
• W1499889283 hasAuthorship W1499889283A5076771279 @default.
• W1499889283 hasBestOaLocation W14998892831 @default.
• W1499889283 hasConcept C126322002 @default.
• W1499889283 hasConcept C185592680 @default.
• W1499889283 hasConcept C55493867 @default.
• W1499889283 hasConcept C71924100 @default.
• W1499889283 hasConceptScore W1499889283C126322002 @default.
• W1499889283 hasConceptScore W1499889283C185592680 @default.
• W1499889283 hasConceptScore W1499889283C55493867 @default.
• W1499889283 hasConceptScore W1499889283C71924100 @default.
• W1499889283 hasIssue "26" @default.
• W1499889283 hasLocation W14998892831 @default.
• W1499889283 hasOpenAccess W1499889283 @default.
• W1499889283 hasPrimaryLocation W14998892831 @default.
• W1499889283 hasRelatedWork W1531601525 @default.
• W1499889283 hasRelatedWork W1990781990 @default.
• W1499889283 hasRelatedWork W2314643286 @default.
• W1499889283 hasRelatedWork W2606768298 @default.
• W1499889283 hasRelatedWork W2606769243 @default.
• W1499889283 hasRelatedWork W2606837276 @default.
• W1499889283 hasRelatedWork W2748952813 @default.
• W1499889283 hasRelatedWork W2899084033 @default.
• W1499889283 hasRelatedWork W2948807893 @default.
• W1499889283 hasRelatedWork W2778153218 @default.
• W1499889283 hasVolume "260" @default.
• W1499889283 isParatext "false" @default.
• W1499889283 isRetracted "false" @default.
• W1499889283 magId "1499889283" @default.
• W1499889283 workType "article" @default.