Matches in SemOpenAlex for { <https://semopenalex.org/work/W1499952282> ?p ?o ?g. }
- W1499952282 abstract "This chapter describes the synthesis and in vitro pharmacology of a novel series of dopamine receptor ligands, in which the classical phenylethylamine pharmacophore is replaced by a thienylethylamine moiety. In general, the novel compounds showed moderate affinity for the dopamine D2 and D3 receptors. The results showed that a thienylethylamine moiety can act as a dopamine pharmacophore on these receptors. When the thienylethylamine moiety is fixed in a rigid system the affinity for the dopamine receptor is increased, however, in the tricyclic hexahydrothianaphthoxazine structure, the affinity for the dopamine receptors is diminished. * This chapter is based on: Rodenhuis, N.; Vermeulen, E.S.; Wikstrom, H.V.; Pugsley, T.A.; Wise, L.D.; Dijkstra, D. (2000) Further characterization of structural requirements for ligands at the dopamine D2 and D3 receptor: studies with thienylethylamines as a possible pharmacophore. J. Med. Chem. submitted." @default.
- W1499952282 created "2016-06-24" @default.
- W1499952282 creator A5025888532 @default.
- W1499952282 date "2000-01-01" @default.
- W1499952282 modified "2023-09-25" @default.
- W1499952282 title "New, centrally acting dopaminergic agents with an improved oral bioavailability: synthesis and pharmacological evaluation" @default.
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