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• W1499971625 abstract "The advent of electrospray ionisation (ESI) has been a major factor driving therevolution which has taken place in the field of biological mass spectrometry overthe past twenty years. In this thesis, efforts to improve electrospray ionisation intwo respects are detailed. One is the transmission of ions from ambient pressureinto the high vacuum of a mass spectrometer. The other is control and influenceover making and breaking of bonds, in particular long and weak bonds, duringthis journey into the mass spectrometer.These improvements to electrospray ionisation have been sought through thedevelopment, theoretical analysis and application of the ion conveyor, which is anelectrodynamic ion-transport device. The ion conveyor as reported here is adevice consisting of stacked ring-electrodes intended for operation within the firstand second differential-pumping regions of a mass spectrometer with anelectrospray ionisation source. It is demonstrated how the ion conveyor achievesaspects of ion trapping and ion transport through the application of one or moreradiofrequency waves to the stacked ring-electrodes. The operating principles ofthe device are detailed, and related technologies are described. Theoreticalsimulations have been used to explore for explanations for the behaviour of thedevice and to make predictions as to the optimum performance of the device.The first experiments with an ion conveyor and subsequent experiments with twoevolved designs are described. The operation of the device has beeninvestigated with three different types of mass spectrometer, each with its owndesign of electrospray ionisation source. These designs are described in detail,and the responses of the ion conveyor to various operating parameters havebeen characterised. A major finding was that the transmission of the ion conveyorremains significantly high in the absence of all applied potentials. This discoveryreveals and emphasises the importance of mechanical forces to ion transportthrough the ion conveyor.A wide variety of analytes have been used in experiments to characterise thedevice. The mass spectra of vancomycin hydrochloride presented are ofparticular note, because they exhibit unusually intense peaks corresponding tothe doubly charged dimer-species. The dimer of vancomycin plays the centralrole in long-standing theories of anti-bacterial action, but has not been observedin previous studies of vancomycin by mass spectrometry.The experimental results support the view that the ion conveyor is a usefultechnique for the effective transport of ions through the differential-pumpingstages of an electrospray ionisation source. The results suggests that the devicecould be developed through appropriate manipulation of ion-neutral collisions inthe higher-pressure regions to preserve and transmit delicate non-covalentlybound species and facilitate their accurate measurement by means of massspectrometry." @default.
• W1499971625 created "2016-06-24" @default.
• W1499971625 creator A5088714537 @default.
• W1499971625 date "2010-02-01" @default.
• W1499971625 modified "2023-09-27" @default.
• W1499971625 title "The ion conveyor : an ion focussing and conveying device for mass spectrometry" @default.
• W1499971625 hasPublicationYear "2010" @default.
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