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• W1500111444 abstract "Abstract : As cells progress through the various phases of the cell cycle the levels of most of the mammalian cyclins fluctuate dramatically. The major protease involved in the removal of cell cycle proteins is the fully regulated 26S proteasome, a multicatalytic protease responsible for the degradation of polyubiquitinated proteins (Glas et al. 1998). In vitro, inhibition of proteasome function prevents cell cycle progression and arrests cells at various stages of the cell cycle. Therefore, proteasome inhibitors like bortezomib (also known as PS-341 or Velcade) or Marizomib (also known as NPI-0052 or salinosporamide A) have been used to target cancer clinically (Kane et al. 2003). However, proteasome inhibitors alone failed to show significant anti-tumor activity and their combination with radiotherapy or established anticancer agents seems to be more promising. Many chemotherapeutic agents as well as radiation have differential efficacy against cancer cells in different phases of the cell cycle. Furthermore, certain chemotherapeutic drugs (Piccinini et al. 2001; Fekete et al. 2005) as well as ionizing radiation (Pajonk et al. 2001) affect proteasome function directly. Exact understanding of when and to which extent proteasome function is affected by a treatment modality is essential in order to better time the application of proteasome inhibitors in the clinic. Investigating the role of the proteasome in different prostate cancer cell subpopulations could be fundamental for the development of more specific and efficient therapies. In fact, both prostate cancer and benign prostatic hyperplasia are believed to arise as a result of changes in the balance between cell proliferation and differentiation (Isaacs et al. 1989; Bonkhoff et al. 1996). Experimental evidence suggests that the malignant transformation originates in a subset of primitive cells meanwhile most cells in an organ do not generate tumors (Huntly et al. 2004; Barker et al. 2009). In the previous year, we focused" @default.
• W1500111444 created "2016-06-24" @default.
• W1500111444 creator A5044488631 @default.
• W1500111444 date "2008-02-01" @default.
• W1500111444 modified "2023-09-23" @default.
• W1500111444 title "Effects of Radiation on Proteasome Function in Prostate Cancer Cells" @default.
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• W1500111444 doi "https://doi.org/10.21236/ada482388" @default.
• W1500111444 hasPublicationYear "2008" @default.
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