FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1500234295> ?p ?o ?g. }

• W1500234295 endingPage "485" @default.
• W1500234295 startingPage "477" @default.
• W1500234295 abstract "Drug-induced liver injury (DILI) is the most common organ toxicity encountered in regulatory animal toxicology studies required prior to the clinical development of new drug candidates. Very few reports have evaluated the value of these studies for predicting DILI in humans. Indeed, compounds inducing liver toxicity in regulatory toxicology studies are not always correlated with a risk of DILI in humans. Conversely, compounds associated with the occurrence of DILI in phase 3 studies or after market release are often tested negative in regulatory toxicology studies. Idiosyncratic DILI is a rare event that is precipitated in an individual by the simultaneous occurrence of several critical factors. These factors may relate to the host (e.g. human leukocyte antigen polymorphism, inflammation), the drug (e.g. reactive metabolites) or the environment (e.g. diet/microbiota). This type of toxicity therefore cannot be detected in conventional animal toxicology studies. Several animal models have recently been proposed for the identification of drugs with the potential to cause idiosyncratic DILI: rats treated with lipopolysaccharide, Sod2^+/- mice, panels of inbred mouse strains or chimeric mice with humanized livers. These models are not suitable for use in the prospective screening of new drug candidates. Humans therefore constitute the best model for predicting and assessing idiopathic DILI." @default.
• W1500234295 created "2016-06-24" @default.
• W1500234295 creator A5004390324 @default.
• W1500234295 date "2015-01-01" @default.
• W1500234295 modified "2023-10-15" @default.
• W1500234295 title "Preventing Drug-Induced Liver Injury: How Useful Are Animal Models?" @default.
• W1500234295 cites W1525464385 @default.
• W1500234295 cites W1966268750 @default.
• W1500234295 cites W1969780974 @default.
• W1500234295 cites W1977229182 @default.
• W1500234295 cites W1979018219 @default.
• W1500234295 cites W1979437648 @default.
• W1500234295 cites W1981438405 @default.
• W1500234295 cites W1993869331 @default.
• W1500234295 cites W2000066924 @default.
• W1500234295 cites W2008428053 @default.
• W1500234295 cites W2015021844 @default.
• W1500234295 cites W2017946433 @default.
• W1500234295 cites W2022868257 @default.
• W1500234295 cites W2028042832 @default.
• W1500234295 cites W2030065489 @default.
• W1500234295 cites W2032504137 @default.
• W1500234295 cites W2037199469 @default.
• W1500234295 cites W2062717014 @default.
• W1500234295 cites W2069005506 @default.
• W1500234295 cites W2069988713 @default.
• W1500234295 cites W2074240508 @default.
• W1500234295 cites W2074545478 @default.
• W1500234295 cites W2076781542 @default.
• W1500234295 cites W2083291372 @default.
• W1500234295 cites W2084508135 @default.
• W1500234295 cites W2085426524 @default.
• W1500234295 cites W2087495628 @default.
• W1500234295 cites W2091508395 @default.
• W1500234295 cites W2104209550 @default.
• W1500234295 cites W2110913099 @default.
• W1500234295 cites W2123759002 @default.
• W1500234295 cites W2130115555 @default.
• W1500234295 cites W2137141250 @default.
• W1500234295 cites W2138150621 @default.
• W1500234295 cites W2138201468 @default.
• W1500234295 cites W2157706038 @default.
• W1500234295 cites W2158961706 @default.
• W1500234295 cites W2159632264 @default.
• W1500234295 cites W2160896286 @default.
• W1500234295 cites W2161643992 @default.
• W1500234295 cites W2169441188 @default.
• W1500234295 cites W2170381017 @default.
• W1500234295 cites W2171421217 @default.
• W1500234295 cites W2327070670 @default.
• W1500234295 cites W38847137 @default.
• W1500234295 cites W4245271255 @default.
• W1500234295 doi "https://doi.org/10.1159/000374093" @default.
• W1500234295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26159262" @default.
• W1500234295 hasPublicationYear "2015" @default.
• W1500234295 type Work @default.
• W1500234295 sameAs 1500234295 @default.
• W1500234295 citedByCount "22" @default.
• W1500234295 countsByYear W15002342952016 @default.
• W1500234295 countsByYear W15002342952017 @default.
• W1500234295 countsByYear W15002342952018 @default.
• W1500234295 countsByYear W15002342952019 @default.
• W1500234295 countsByYear W15002342952020 @default.
• W1500234295 countsByYear W15002342952021 @default.
• W1500234295 countsByYear W15002342952022 @default.
• W1500234295 crossrefType "journal-article" @default.
• W1500234295 hasAuthorship W1500234295A5004390324 @default.
• W1500234295 hasConcept C126322002 @default.
• W1500234295 hasConcept C172268261 @default.
• W1500234295 hasConcept C2776637226 @default.
• W1500234295 hasConcept C2778117688 @default.
• W1500234295 hasConcept C2780035454 @default.
• W1500234295 hasConcept C29730261 @default.
• W1500234295 hasConcept C2993709057 @default.
• W1500234295 hasConcept C60644358 @default.
• W1500234295 hasConcept C64903051 @default.
• W1500234295 hasConcept C71924100 @default.
• W1500234295 hasConcept C86803240 @default.
• W1500234295 hasConcept C89311334 @default.
• W1500234295 hasConcept C98274493 @default.
• W1500234295 hasConceptScore W1500234295C126322002 @default.
• W1500234295 hasConceptScore W1500234295C172268261 @default.
• W1500234295 hasConceptScore W1500234295C2776637226 @default.
• W1500234295 hasConceptScore W1500234295C2778117688 @default.
• W1500234295 hasConceptScore W1500234295C2780035454 @default.
• W1500234295 hasConceptScore W1500234295C29730261 @default.
• W1500234295 hasConceptScore W1500234295C2993709057 @default.
• W1500234295 hasConceptScore W1500234295C60644358 @default.
• W1500234295 hasConceptScore W1500234295C64903051 @default.
• W1500234295 hasConceptScore W1500234295C71924100 @default.
• W1500234295 hasConceptScore W1500234295C86803240 @default.
• W1500234295 hasConceptScore W1500234295C89311334 @default.
• W1500234295 hasConceptScore W1500234295C98274493 @default.
• W1500234295 hasIssue "4" @default.
• W1500234295 hasLocation W15002342951 @default.
• W1500234295 hasLocation W15002342952 @default.
• W1500234295 hasOpenAccess W1500234295 @default.
• W1500234295 hasPrimaryLocation W15002342951 @default.

• next