FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1500378982> ?p ?o ?g. }

• W1500378982 endingPage "6680" @default.
• W1500378982 startingPage "6674" @default.
• W1500378982 abstract "Abstract To investigate the diversity of the T cell repertoire involved in human T lymphotropic virus type I (HTLV-I) infections, peripheral blood T cell subsets were analyzed by using a PCR-based assay that permits determination of complementarity-determining region 3 (CDR3) length variation in TCR Vβ transcripts. In two of four asymptomatic HTLV-I carriers and in four of five patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), mono- or oligoclonal expansions were detected in the CD4+ T cell subset. In one patient with adult T cell leukemia, a specific clone bearing Vβ7 was detected in the CD4+ T cell subset. In contrast, clonal expansion was not observed in the CD4 T cell subsets of three individuals with asymptomatic HTLV-II infection or in our previous studies of a large number of uninfected individuals. Oligoclonal expansions in the CD8+ T cell subset were detected in all subjects, including the patient with adult T cell leukemia. No differences in the number of expanded clones were noted between asymptomatic carriers and in patients with HAM/TSP and there was no obvious restriction in the TCR V region usage. Direct sequencing revealed no significant bias in the CDR3 motifs utilized by the predominant clones. This report is the first direct demonstration of clonal expansions within fractionated T cell subsets (CD4+ and CD8+) in HTLV-I infections and suggests that 1) clonal expansion of CD4+ T lymphocytes likely occurs as a direct result of infection and 2) polyclonal CD8+ T cell expansion occurs frequently and independently of disease association." @default.
• W1500378982 created "2016-06-24" @default.
• W1500378982 creator A5009523530 @default.
• W1500378982 creator A5034633787 @default.
• W1500378982 creator A5060215575 @default.
• W1500378982 creator A5069320624 @default.
• W1500378982 creator A5075143481 @default.
• W1500378982 creator A5077751499 @default.
• W1500378982 creator A5079456615 @default.
• W1500378982 creator A5082248535 @default.
• W1500378982 creator A5082512143 @default.
• W1500378982 creator A5087638434 @default.
• W1500378982 creator A5089097521 @default.
• W1500378982 date "1998-12-15" @default.
• W1500378982 modified "2023-10-10" @default.
• W1500378982 title "Clonal Expansion Within CD4+ and CD8+ T Cell Subsets in Human T Lymphotropic Virus Type I-Infected Individuals" @default.
• W1500378982 cites W1481504784 @default.
• W1500378982 cites W1481979720 @default.
• W1500378982 cites W1541479364 @default.
• W1500378982 cites W1586205537 @default.
• W1500378982 cites W1602082549 @default.
• W1500378982 cites W1604816862 @default.
• W1500378982 cites W1966528056 @default.
• W1500378982 cites W1969937142 @default.
• W1500378982 cites W1971998039 @default.
• W1500378982 cites W1973693632 @default.
• W1500378982 cites W1976093076 @default.
• W1500378982 cites W1979894670 @default.
• W1500378982 cites W1981796830 @default.
• W1500378982 cites W1994602933 @default.
• W1500378982 cites W1995901517 @default.
• W1500378982 cites W2007789137 @default.
• W1500378982 cites W2009166226 @default.
• W1500378982 cites W2016899885 @default.
• W1500378982 cites W2034793464 @default.
• W1500378982 cites W2037374528 @default.
• W1500378982 cites W2045033555 @default.
• W1500378982 cites W2048934884 @default.
• W1500378982 cites W2050554528 @default.
• W1500378982 cites W2050905464 @default.
• W1500378982 cites W2060264122 @default.
• W1500378982 cites W2060437233 @default.
• W1500378982 cites W2078298372 @default.
• W1500378982 cites W2080196315 @default.
• W1500378982 cites W2084714153 @default.
• W1500378982 cites W2087102119 @default.
• W1500378982 cites W2089048401 @default.
• W1500378982 cites W2107961028 @default.
• W1500378982 cites W2121082919 @default.
• W1500378982 cites W2123823922 @default.
• W1500378982 cites W2126663486 @default.
• W1500378982 cites W2127325577 @default.
• W1500378982 cites W2139432296 @default.
• W1500378982 cites W2143682039 @default.
• W1500378982 cites W2150908206 @default.
• W1500378982 cites W2152256013 @default.
• W1500378982 cites W2158178382 @default.
• W1500378982 cites W2269404894 @default.
• W1500378982 cites W2336211911 @default.
• W1500378982 cites W2526215756 @default.
• W1500378982 cites W2784027154 @default.
• W1500378982 cites W4239426639 @default.
• W1500378982 cites W4252629767 @default.
• W1500378982 cites W86279991 @default.
• W1500378982 doi "https://doi.org/10.4049/jimmunol.161.12.6674" @default.
• W1500378982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9862696" @default.
• W1500378982 hasPublicationYear "1998" @default.
• W1500378982 type Work @default.
• W1500378982 sameAs 1500378982 @default.
• W1500378982 citedByCount "40" @default.
• W1500378982 countsByYear W15003789822012 @default.
• W1500378982 countsByYear W15003789822013 @default.
• W1500378982 countsByYear W15003789822014 @default.
• W1500378982 countsByYear W15003789822015 @default.
• W1500378982 countsByYear W15003789822016 @default.
• W1500378982 countsByYear W15003789822017 @default.
• W1500378982 countsByYear W15003789822019 @default.
• W1500378982 countsByYear W15003789822021 @default.
• W1500378982 countsByYear W15003789822022 @default.
• W1500378982 countsByYear W15003789822023 @default.
• W1500378982 crossrefType "journal-article" @default.
• W1500378982 hasAuthorship W1500378982A5009523530 @default.
• W1500378982 hasAuthorship W1500378982A5034633787 @default.
• W1500378982 hasAuthorship W1500378982A5060215575 @default.
• W1500378982 hasAuthorship W1500378982A5069320624 @default.
• W1500378982 hasAuthorship W1500378982A5075143481 @default.
• W1500378982 hasAuthorship W1500378982A5077751499 @default.
• W1500378982 hasAuthorship W1500378982A5079456615 @default.
• W1500378982 hasAuthorship W1500378982A5082248535 @default.
• W1500378982 hasAuthorship W1500378982A5082512143 @default.
• W1500378982 hasAuthorship W1500378982A5087638434 @default.
• W1500378982 hasAuthorship W1500378982A5089097521 @default.
• W1500378982 hasBestOaLocation W15003789821 @default.
• W1500378982 hasConcept C104317684 @default.
• W1500378982 hasConcept C137916694 @default.
• W1500378982 hasConcept C142724271 @default.
• W1500378982 hasConcept C147483822 @default.
• W1500378982 hasConcept C159047783 @default.

• next