Matches in SemOpenAlex for { <https://semopenalex.org/work/W1500468340> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1500468340 endingPage "e19" @default.
- W1500468340 startingPage "e16" @default.
- W1500468340 abstract "Antiepileptic drugs (AEDs) can lower maternal folate and increase maternal homocysteine levels, which are known to affect the methyl cycle and hence DNA methylation levels. The influence of in utero exposure to AEDs on fetal DNA methylation was investigated. Genome-wide fetal epigenomic profiles were determined using the Infinium 27K BeadArray from Illumina (San Diego, CA, U.S.A.). The Infinium array measures approximately 27,000 CpG loci associated with 14,496 genes at single-nucleotide resolution. Eighteen cord blood samples (nine samples from babies exposed to AEDs and nine controls) from otherwise uncomplicated pregnancies were compared. Unsupervised hierarchic clustering was used to compare the calculated methylation profiles. A clear distinction between the methylation profiles of samples from babies exposed to AEDs in utero compared with controls was detected. These data provide evidence of an epigenetic effect associated with antenatal AED and high-dose folate supplementation during pregnancy. The differences in fetal DNA methylation of those exposed to AEDs shows that a genome-wide effect of methylation is evident. In addition, the epigenetic changes observed appear to be, in this limited sample, independent of extremes of birth weight centiles. These preliminary data highlight possible mechanisms by which AEDs might influence fetal outcomes and the potential of optimizing AED-specific folate supplementation regimens to offset these effects." @default.
- W1500468340 created "2016-06-24" @default.
- W1500468340 creator A5017881471 @default.
- W1500468340 creator A5031394822 @default.
- W1500468340 creator A5047795251 @default.
- W1500468340 creator A5055727064 @default.
- W1500468340 creator A5059715703 @default.
- W1500468340 creator A5081245556 @default.
- W1500468340 creator A5081480113 @default.
- W1500468340 date "2012-09-27" @default.
- W1500468340 modified "2023-09-25" @default.
- W1500468340 title "Antiepileptic drugs and the fetal epigenome" @default.
- W1500468340 cites W1966442862 @default.
- W1500468340 cites W1998970086 @default.
- W1500468340 cites W2011474247 @default.
- W1500468340 cites W2023924759 @default.
- W1500468340 cites W2027901910 @default.
- W1500468340 cites W2071049267 @default.
- W1500468340 cites W2089003540 @default.
- W1500468340 cites W2114970231 @default.
- W1500468340 cites W2144201419 @default.
- W1500468340 cites W2146629358 @default.
- W1500468340 cites W2169099940 @default.
- W1500468340 cites W4291305102 @default.
- W1500468340 doi "https://doi.org/10.1111/j.1528-1167.2012.03673.x" @default.
- W1500468340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23016625" @default.
- W1500468340 hasPublicationYear "2012" @default.
- W1500468340 type Work @default.
- W1500468340 sameAs 1500468340 @default.
- W1500468340 citedByCount "9" @default.
- W1500468340 countsByYear W15004683402014 @default.
- W1500468340 countsByYear W15004683402015 @default.
- W1500468340 countsByYear W15004683402016 @default.
- W1500468340 countsByYear W15004683402017 @default.
- W1500468340 countsByYear W15004683402018 @default.
- W1500468340 countsByYear W15004683402021 @default.
- W1500468340 crossrefType "journal-article" @default.
- W1500468340 hasAuthorship W1500468340A5017881471 @default.
- W1500468340 hasAuthorship W1500468340A5031394822 @default.
- W1500468340 hasAuthorship W1500468340A5047795251 @default.
- W1500468340 hasAuthorship W1500468340A5055727064 @default.
- W1500468340 hasAuthorship W1500468340A5059715703 @default.
- W1500468340 hasAuthorship W1500468340A5081245556 @default.
- W1500468340 hasAuthorship W1500468340A5081480113 @default.
- W1500468340 hasBestOaLocation W15004683401 @default.
- W1500468340 hasConcept C104317684 @default.
- W1500468340 hasConcept C117717151 @default.
- W1500468340 hasConcept C121912465 @default.
- W1500468340 hasConcept C140173407 @default.
- W1500468340 hasConcept C150194340 @default.
- W1500468340 hasConcept C172680121 @default.
- W1500468340 hasConcept C190727270 @default.
- W1500468340 hasConcept C201614185 @default.
- W1500468340 hasConcept C2779234561 @default.
- W1500468340 hasConcept C33288867 @default.
- W1500468340 hasConcept C41091548 @default.
- W1500468340 hasConcept C54355233 @default.
- W1500468340 hasConcept C60644358 @default.
- W1500468340 hasConcept C71924100 @default.
- W1500468340 hasConcept C86803240 @default.
- W1500468340 hasConceptScore W1500468340C104317684 @default.
- W1500468340 hasConceptScore W1500468340C117717151 @default.
- W1500468340 hasConceptScore W1500468340C121912465 @default.
- W1500468340 hasConceptScore W1500468340C140173407 @default.
- W1500468340 hasConceptScore W1500468340C150194340 @default.
- W1500468340 hasConceptScore W1500468340C172680121 @default.
- W1500468340 hasConceptScore W1500468340C190727270 @default.
- W1500468340 hasConceptScore W1500468340C201614185 @default.
- W1500468340 hasConceptScore W1500468340C2779234561 @default.
- W1500468340 hasConceptScore W1500468340C33288867 @default.
- W1500468340 hasConceptScore W1500468340C41091548 @default.
- W1500468340 hasConceptScore W1500468340C54355233 @default.
- W1500468340 hasConceptScore W1500468340C60644358 @default.
- W1500468340 hasConceptScore W1500468340C71924100 @default.
- W1500468340 hasConceptScore W1500468340C86803240 @default.
- W1500468340 hasIssue "1" @default.
- W1500468340 hasLocation W15004683401 @default.
- W1500468340 hasLocation W15004683402 @default.
- W1500468340 hasOpenAccess W1500468340 @default.
- W1500468340 hasPrimaryLocation W15004683401 @default.
- W1500468340 hasRelatedWork W1616294352 @default.
- W1500468340 hasRelatedWork W2077359776 @default.
- W1500468340 hasRelatedWork W2142309127 @default.
- W1500468340 hasRelatedWork W2144727750 @default.
- W1500468340 hasRelatedWork W2899730466 @default.
- W1500468340 hasRelatedWork W2906103633 @default.
- W1500468340 hasRelatedWork W2936129299 @default.
- W1500468340 hasRelatedWork W2944764859 @default.
- W1500468340 hasRelatedWork W3045146427 @default.
- W1500468340 hasRelatedWork W3096105463 @default.
- W1500468340 hasVolume "54" @default.
- W1500468340 isParatext "false" @default.
- W1500468340 isRetracted "false" @default.
- W1500468340 magId "1500468340" @default.
- W1500468340 workType "article" @default.