Matches in SemOpenAlex for { <https://semopenalex.org/work/W1500508767> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1500508767 endingPage "6104" @default.
- W1500508767 startingPage "6097" @default.
- W1500508767 abstract "Two molecular forms of prekallikrein can be isolated from pooled normal human plasma. Their approximate molecular weights by sodium dodecyl sulfate-gel electrophoresis are 88,000 and 85,000. The two bands observed are shown to represent prekallikrein by functional, immunochemical, and structural criteria. Both forms are cleaved by activated Hageman factor, they appear to share antigenic determinants, they are not interconvertible upon incubation with activated Hageman factor or kallikrein, and the ratio of kinin-generating, and plasminogen-activating activities of the preparations are independent of the relative proportion of each band. Activated Factor XII converts prekallikrein to kallikrein by limited proteolysis and two disulfide-linked chains designated kallikrein heavy chain (Mr = 52,000) and kallikrein light chains (Mr = 36,000 or 33,000) are formed. The active site is associated with the light chains as assessed by incorporation of [3H]diisopropyl fluorophosphate. No dissociable fragments were observed in the absence of reducing agents. However, kallikrein could digest prekallikrein to diminish its molecular weight by 10,000. In addition, two factors capable of activating plasminogen to plasmin have been isolated; one is identified as kallikrein. The second principle fractionates with Factor XI and is demonstrable in normal and prekallikrein-deficient plasma." @default.
- W1500508767 created "2016-06-24" @default.
- W1500508767 creator A5053946031 @default.
- W1500508767 creator A5066320269 @default.
- W1500508767 date "1977-09-01" @default.
- W1500508767 modified "2023-10-17" @default.
- W1500508767 title "Hageman factor substrates. Human plasma prekallikrein: mechanism of activation by Hageman factor and participation in hageman factor-dependent fibrinolysis." @default.
- W1500508767 cites W1628373838 @default.
- W1500508767 cites W1775749144 @default.
- W1500508767 cites W1893651774 @default.
- W1500508767 cites W1990942696 @default.
- W1500508767 cites W2004908853 @default.
- W1500508767 cites W2012839797 @default.
- W1500508767 cites W2022612342 @default.
- W1500508767 cites W2025562266 @default.
- W1500508767 cites W2034124407 @default.
- W1500508767 cites W2034277598 @default.
- W1500508767 cites W2058381769 @default.
- W1500508767 cites W2059659031 @default.
- W1500508767 cites W2060519728 @default.
- W1500508767 cites W2080779467 @default.
- W1500508767 cites W2091849415 @default.
- W1500508767 cites W2092462079 @default.
- W1500508767 cites W2093213625 @default.
- W1500508767 cites W2106321676 @default.
- W1500508767 cites W2109782036 @default.
- W1500508767 cites W2114824337 @default.
- W1500508767 cites W2123210321 @default.
- W1500508767 cites W2132068224 @default.
- W1500508767 cites W2151463374 @default.
- W1500508767 cites W2333330110 @default.
- W1500508767 cites W2429409376 @default.
- W1500508767 doi "https://doi.org/10.1016/s0021-9258(17)40034-2" @default.
- W1500508767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/408348" @default.
- W1500508767 hasPublicationYear "1977" @default.
- W1500508767 type Work @default.
- W1500508767 sameAs 1500508767 @default.
- W1500508767 citedByCount "187" @default.
- W1500508767 countsByYear W15005087672012 @default.
- W1500508767 countsByYear W15005087672013 @default.
- W1500508767 countsByYear W15005087672014 @default.
- W1500508767 countsByYear W15005087672015 @default.
- W1500508767 countsByYear W15005087672016 @default.
- W1500508767 countsByYear W15005087672019 @default.
- W1500508767 countsByYear W15005087672020 @default.
- W1500508767 countsByYear W15005087672021 @default.
- W1500508767 countsByYear W15005087672022 @default.
- W1500508767 crossrefType "journal-article" @default.
- W1500508767 hasAuthorship W1500508767A5053946031 @default.
- W1500508767 hasAuthorship W1500508767A5066320269 @default.
- W1500508767 hasBestOaLocation W15005087671 @default.
- W1500508767 hasConcept C126322002 @default.
- W1500508767 hasConcept C152328610 @default.
- W1500508767 hasConcept C181199279 @default.
- W1500508767 hasConcept C185592680 @default.
- W1500508767 hasConcept C2776825266 @default.
- W1500508767 hasConcept C2777167447 @default.
- W1500508767 hasConcept C2778382381 @default.
- W1500508767 hasConcept C52853521 @default.
- W1500508767 hasConcept C55493867 @default.
- W1500508767 hasConcept C71924100 @default.
- W1500508767 hasConceptScore W1500508767C126322002 @default.
- W1500508767 hasConceptScore W1500508767C152328610 @default.
- W1500508767 hasConceptScore W1500508767C181199279 @default.
- W1500508767 hasConceptScore W1500508767C185592680 @default.
- W1500508767 hasConceptScore W1500508767C2776825266 @default.
- W1500508767 hasConceptScore W1500508767C2777167447 @default.
- W1500508767 hasConceptScore W1500508767C2778382381 @default.
- W1500508767 hasConceptScore W1500508767C52853521 @default.
- W1500508767 hasConceptScore W1500508767C55493867 @default.
- W1500508767 hasConceptScore W1500508767C71924100 @default.
- W1500508767 hasIssue "17" @default.
- W1500508767 hasLocation W15005087671 @default.
- W1500508767 hasOpenAccess W1500508767 @default.
- W1500508767 hasPrimaryLocation W15005087671 @default.
- W1500508767 hasRelatedWork W1888682425 @default.
- W1500508767 hasRelatedWork W195569127 @default.
- W1500508767 hasRelatedWork W1967508759 @default.
- W1500508767 hasRelatedWork W2081334010 @default.
- W1500508767 hasRelatedWork W2087037963 @default.
- W1500508767 hasRelatedWork W2109782036 @default.
- W1500508767 hasRelatedWork W2412083320 @default.
- W1500508767 hasRelatedWork W2417652550 @default.
- W1500508767 hasRelatedWork W4249693989 @default.
- W1500508767 hasRelatedWork W63247547 @default.
- W1500508767 hasVolume "252" @default.
- W1500508767 isParatext "false" @default.
- W1500508767 isRetracted "false" @default.
- W1500508767 magId "1500508767" @default.
- W1500508767 workType "article" @default.