FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1500516478> ?p ?o ?g. }

• W1500516478 endingPage "12382" @default.
• W1500516478 startingPage "12375" @default.
• W1500516478 abstract "Although some previous studies have suggested that triglyceride, a major core lipid, plays a key role in the assembly and secretion of apolipoprotein B-containing lipoproteins from HepG2 cells, other reports have indicated the importance of cholesteryl ester, another core lipid. We attempted to better define the roles of triglyceride and cholesteryl ester in the assembly and secretion of apolipoprotein B-containing lipoproteins from HepG2 cells by determining the effects of Sandoz 58-035, a potent acyl-CoA acyltransferase inhibitor, which significantly inhibits cholesteryl synthesis, and Triacsin D, a potent fatty acyl-CoA synthetase inhibitor, which significantly inhibits triglyceride synthesis, on the secretion of apolipoprotein B-containing lipoproteins. Sandoz 58-035 (2 micrograms/ml) decreased very low density lipoproteins (VLDL)-stimulated cellular cholesteryl ester content by 60-80%, and blocked oleate-stimulated cholesteryl ester synthesis by 100%, but did not decrease VLDL- or oleate-stimulated apolipoprotein B secretion. Triacsin D (12.5 microM), which significantly inhibited VLDL and oleate stimulation of triglyceride synthesis, without affecting cholesteryl ester synthesis, blocked the stimulation of apolipoprotein B secretion by both agents. In HepG2 cells transfected with 3-hydroxy-methylglutaryl-CoA reductase cDNA, cholesteryl ester synthesis and mass were increased by 100%, but apolipoprotein B secretion was unaffected. Sandoz 58-035 decreased cholesteryl ester synthesis significantly but did not decrease apolipoprotein B secretion from this cell line. When these transfected cells were incubated with oleate, apolipoprotein B secretion increased; Triacsin D blocked this effect. Finally, sphingomyelinase treatment (which shifts cholesterol from plasma membranes to intracellular pools) increased cholesteryl ester synthesis 4-5-fold, but apolipoprotein B secretion was unaffected. Changes in cellular cholesteryl ester synthesis or mass did not affect the intracellular degradation of newly synthesized apolipoprotein B, but changes in triglyceride synthesis were always associated with corresponding changes in the intracellular degradation of apolipoprotein B. In conclusion, neither long term nor short term changes in cholesteryl ester synthesis or mass regulate the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells." @default.
• W1500516478 created "2016-06-24" @default.
• W1500516478 creator A5003172277 @default.
• W1500516478 creator A5007048045 @default.
• W1500516478 creator A5013873454 @default.
• W1500516478 creator A5040653383 @default.
• W1500516478 date "1994-04-01" @default.
• W1500516478 modified "2023-10-15" @default.
• W1500516478 title "Evidence for a lack of regulation of the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells by cholesteryl ester." @default.
• W1500516478 cites W1486210853 @default.
• W1500516478 cites W1489909412 @default.
• W1500516478 cites W1515368893 @default.
• W1500516478 cites W1531590060 @default.
• W1500516478 cites W1535964227 @default.
• W1500516478 cites W1541183759 @default.
• W1500516478 cites W1551374056 @default.
• W1500516478 cites W1557907146 @default.
• W1500516478 cites W1579835576 @default.
• W1500516478 cites W1586986973 @default.
• W1500516478 cites W1599366995 @default.
• W1500516478 cites W1599596785 @default.
• W1500516478 cites W1821737351 @default.
• W1500516478 cites W1898264975 @default.
• W1500516478 cites W1906747518 @default.
• W1500516478 cites W1921601722 @default.
• W1500516478 cites W1956183677 @default.
• W1500516478 cites W1970997914 @default.
• W1500516478 cites W1972040123 @default.
• W1500516478 cites W2010923530 @default.
• W1500516478 cites W2026901473 @default.
• W1500516478 cites W2050286352 @default.
• W1500516478 cites W2067406978 @default.
• W1500516478 cites W2069146701 @default.
• W1500516478 cites W2079897891 @default.
• W1500516478 cites W2081466710 @default.
• W1500516478 cites W2108445985 @default.
• W1500516478 cites W2116890637 @default.
• W1500516478 cites W2123545493 @default.
• W1500516478 cites W2142750016 @default.
• W1500516478 cites W2157680057 @default.
• W1500516478 cites W2167396380 @default.
• W1500516478 cites W2335950035 @default.
• W1500516478 cites W2394146660 @default.
• W1500516478 cites W4232534952 @default.
• W1500516478 doi "https://doi.org/10.1016/s0021-9258(17)32726-6" @default.
• W1500516478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8163541" @default.
• W1500516478 hasPublicationYear "1994" @default.
• W1500516478 type Work @default.
• W1500516478 sameAs 1500516478 @default.
• W1500516478 citedByCount "117" @default.
• W1500516478 countsByYear W15005164782013 @default.
• W1500516478 countsByYear W15005164782023 @default.
• W1500516478 crossrefType "journal-article" @default.
• W1500516478 hasAuthorship W1500516478A5003172277 @default.
• W1500516478 hasAuthorship W1500516478A5007048045 @default.
• W1500516478 hasAuthorship W1500516478A5013873454 @default.
• W1500516478 hasAuthorship W1500516478A5040653383 @default.
• W1500516478 hasBestOaLocation W15005164781 @default.
• W1500516478 hasConcept C126322002 @default.
• W1500516478 hasConcept C134018914 @default.
• W1500516478 hasConcept C185592680 @default.
• W1500516478 hasConcept C2776448209 @default.
• W1500516478 hasConcept C2778163477 @default.
• W1500516478 hasConcept C2780072125 @default.
• W1500516478 hasConcept C49039625 @default.
• W1500516478 hasConcept C55493867 @default.
• W1500516478 hasConcept C62746215 @default.
• W1500516478 hasConcept C71924100 @default.
• W1500516478 hasConcept C86803240 @default.
• W1500516478 hasConceptScore W1500516478C126322002 @default.
• W1500516478 hasConceptScore W1500516478C134018914 @default.
• W1500516478 hasConceptScore W1500516478C185592680 @default.
• W1500516478 hasConceptScore W1500516478C2776448209 @default.
• W1500516478 hasConceptScore W1500516478C2778163477 @default.
• W1500516478 hasConceptScore W1500516478C2780072125 @default.
• W1500516478 hasConceptScore W1500516478C49039625 @default.
• W1500516478 hasConceptScore W1500516478C55493867 @default.
• W1500516478 hasConceptScore W1500516478C62746215 @default.
• W1500516478 hasConceptScore W1500516478C71924100 @default.
• W1500516478 hasConceptScore W1500516478C86803240 @default.
• W1500516478 hasIssue "16" @default.
• W1500516478 hasLocation W15005164781 @default.
• W1500516478 hasOpenAccess W1500516478 @default.
• W1500516478 hasPrimaryLocation W15005164781 @default.
• W1500516478 hasRelatedWork W1980266135 @default.
• W1500516478 hasRelatedWork W2017408391 @default.
• W1500516478 hasRelatedWork W2017524567 @default.
• W1500516478 hasRelatedWork W2084628138 @default.
• W1500516478 hasRelatedWork W2101167514 @default.
• W1500516478 hasRelatedWork W2383859375 @default.
• W1500516478 hasRelatedWork W2570447 @default.
• W1500516478 hasRelatedWork W2901608492 @default.
• W1500516478 hasRelatedWork W3147104275 @default.
• W1500516478 hasRelatedWork W4253281463 @default.
• W1500516478 hasVolume "269" @default.
• W1500516478 isParatext "false" @default.
• W1500516478 isRetracted "false" @default.
• W1500516478 magId "1500516478" @default.

• next