FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1500717174> ?p ?o ?g. }

• W1500717174 endingPage "807" @default.
• W1500717174 startingPage "5799" @default.
• W1500717174 abstract "The base excision repair pathway (BER) is believed to maintain genomic integrity by repairing DNA damage arising spontaneously or induced by oxidizing and alkylating agents. To establish the role of DNA polymerase beta (beta-pol) in BER and beta-pol-dependent BER in maintaining genomic stability, we have measured the impact of a gene-targeted disruption in the beta-pol gene on DNA repair capacity and on in vivo sensitivity to carcinogens. We have extensively phenotyped the DNA beta-pol heterozygous (beta-pol(+/-)) mouse as expressing approximately 50% less beta-pol mRNA and protein and as exhibiting an equivalent reduction in the specific activity of beta-pol. We measured BER activity by in vitro G:U mismatch and (8-OH)G:C repair and find that there is a significant reduction in the ability of extracts from beta-pol(+/-) mice to repair these types of DNA damage. In vivo, the beta-pol(+/-) mice sustain higher levels of DNA single-strand breaks as well as increased chromosomal aberrations as compared with beta-pol(+/+) littermates. Additionally, we show that reduction in beta-pol expression and BER activity results in increased mutagenicity of dimethyl sulfate as evidenced by a 2-fold increase in LacI mutation frequency. Importantly, the beta-pol(+/-) mice do not exhibit increased sensitivity to DNA damage induced by N-nitroso-N-ethylurea, ionizing radiation, or UV radiation, which induce damage processed by alternative repair pathways, demonstrating that this model is specifically a BER-deficient model." @default.
• W1500717174 created "2016-06-24" @default.
• W1500717174 creator A5003323104 @default.
• W1500717174 creator A5007364549 @default.
• W1500717174 creator A5027592948 @default.
• W1500717174 creator A5027876809 @default.
• W1500717174 creator A5031461453 @default.
• W1500717174 creator A5061020688 @default.
• W1500717174 creator A5070588827 @default.
• W1500717174 date "2003-09-15" @default.
• W1500717174 modified "2023-09-23" @default.
• W1500717174 title "Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens." @default.
• W1500717174 cites W1485534662 @default.
• W1500717174 cites W1491876634 @default.
• W1500717174 cites W1495268836 @default.
• W1500717174 cites W1514863275 @default.
• W1500717174 cites W1545021361 @default.
• W1500717174 cites W1605349427 @default.
• W1500717174 cites W1676933436 @default.
• W1500717174 cites W182820266 @default.
• W1500717174 cites W1971602039 @default.
• W1500717174 cites W1974585689 @default.
• W1500717174 cites W1975103142 @default.
• W1500717174 cites W1976831386 @default.
• W1500717174 cites W1987430471 @default.
• W1500717174 cites W1994851065 @default.
• W1500717174 cites W2009024472 @default.
• W1500717174 cites W2010992218 @default.
• W1500717174 cites W2011803888 @default.
• W1500717174 cites W2022099770 @default.
• W1500717174 cites W2029243559 @default.
• W1500717174 cites W2035932182 @default.
• W1500717174 cites W2036931505 @default.
• W1500717174 cites W2042699531 @default.
• W1500717174 cites W2048139403 @default.
• W1500717174 cites W2057977031 @default.
• W1500717174 cites W2064163762 @default.
• W1500717174 cites W2064324201 @default.
• W1500717174 cites W2066668773 @default.
• W1500717174 cites W2067546483 @default.
• W1500717174 cites W2076360528 @default.
• W1500717174 cites W2077634990 @default.
• W1500717174 cites W2078685494 @default.
• W1500717174 cites W2085312575 @default.
• W1500717174 cites W2087917559 @default.
• W1500717174 cites W2088336643 @default.
• W1500717174 cites W2090861379 @default.
• W1500717174 cites W2092629964 @default.
• W1500717174 cites W2092845419 @default.
• W1500717174 cites W2094792549 @default.
• W1500717174 cites W2102406570 @default.
• W1500717174 cites W2128635872 @default.
• W1500717174 cites W2132222969 @default.
• W1500717174 cites W2134127409 @default.
• W1500717174 cites W2134428957 @default.
• W1500717174 cites W2134831636 @default.
• W1500717174 cites W2138359988 @default.
• W1500717174 cites W2152026716 @default.
• W1500717174 cites W2165432409 @default.
• W1500717174 cites W1995451939 @default.
• W1500717174 cites W2041171025 @default.
• W1500717174 cites W2575671973 @default.
• W1500717174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14522902" @default.
• W1500717174 hasPublicationYear "2003" @default.
• W1500717174 type Work @default.
• W1500717174 sameAs 1500717174 @default.
• W1500717174 citedByCount "39" @default.
• W1500717174 countsByYear W15007171742012 @default.
• W1500717174 countsByYear W15007171742013 @default.
• W1500717174 countsByYear W15007171742014 @default.
• W1500717174 countsByYear W15007171742015 @default.
• W1500717174 countsByYear W15007171742016 @default.
• W1500717174 countsByYear W15007171742018 @default.
• W1500717174 countsByYear W15007171742019 @default.
• W1500717174 countsByYear W15007171742020 @default.
• W1500717174 countsByYear W15007171742021 @default.
• W1500717174 countsByYear W15007171742022 @default.
• W1500717174 crossrefType "journal-article" @default.
• W1500717174 hasAuthorship W1500717174A5003323104 @default.
• W1500717174 hasAuthorship W1500717174A5007364549 @default.
• W1500717174 hasAuthorship W1500717174A5027592948 @default.
• W1500717174 hasAuthorship W1500717174A5027876809 @default.
• W1500717174 hasAuthorship W1500717174A5031461453 @default.
• W1500717174 hasAuthorship W1500717174A5061020688 @default.
• W1500717174 hasAuthorship W1500717174A5070588827 @default.
• W1500717174 hasConcept C131140672 @default.
• W1500717174 hasConcept C134935766 @default.
• W1500717174 hasConcept C143425029 @default.
• W1500717174 hasConcept C153911025 @default.
• W1500717174 hasConcept C178169997 @default.
• W1500717174 hasConcept C185592680 @default.
• W1500717174 hasConcept C187206112 @default.
• W1500717174 hasConcept C199360897 @default.
• W1500717174 hasConcept C2756471 @default.
• W1500717174 hasConcept C2776174256 @default.
• W1500717174 hasConcept C2778462844 @default.
• W1500717174 hasConcept C41008148 @default.
• W1500717174 hasConcept C54355233 @default.

• next