Matches in SemOpenAlex for { <https://semopenalex.org/work/W1500857601> ?p ?o ?g. }
- W1500857601 endingPage "122" @default.
- W1500857601 startingPage "114" @default.
- W1500857601 abstract "Object To date, experience of globus pallidus internus (GPi) deep brain stimulation (DBS) in the treatment of Huntington's disease (HD) has been limited to a small number of case reports. The aim of this study was to analyze long-term motor outcome of a cohort of HD patients treated with GPi DBS. Methods Seven patients with pharmacologically resistant chorea and functional impairment were included in a prospective open-label study from 2008 to 2011. The main outcome measure was the motor section of the Unified Huntington's Disease Rating Scale. The primary end point was reduction of chorea. Results Patients underwent MRI-guided bilateral GPi implantation. The median duration of follow-up was 3 years. A significant reduction of chorea was observed in all patients, with sustained therapeutic effect; the mean improvement on the chorea subscore was 58.34% at the 12-month follow-up visit (p = 0.018) and 59.8% at the 3-year visit (p = 0.040). Bradykinesia and dystonia showed a nonsignificant trend toward progressive worsening related to disease evolution and partly to DBS. The frequency of stimulation was 130 Hz for all patients. DBS-induced bradykinesia was managed by pulse-width reduction or bipolar settings. Levodopa mildly improved bradykinesia in 4 patients. Regular off-stimulation tests confirmed a persistent therapeutic effect of DBS on chorea. Conclusions GPi DBS may provide sustained chorea improvement in selected HD patients with pharmacologically resistant chorea, with transient benefit in physical aspects of quality of life before progression of behavioral and cognitive disorders. DBS therapy did not improve dystonia or bradykinesia. Further studies including quality of life measures are needed to evaluate the impact of DBS in the long-term outcome of HD." @default.
- W1500857601 created "2016-06-24" @default.
- W1500857601 creator A5014176161 @default.
- W1500857601 creator A5016425817 @default.
- W1500857601 creator A5045189387 @default.
- W1500857601 creator A5045972001 @default.
- W1500857601 creator A5047553528 @default.
- W1500857601 creator A5055157209 @default.
- W1500857601 creator A5060770453 @default.
- W1500857601 creator A5069054328 @default.
- W1500857601 creator A5077802711 @default.
- W1500857601 creator A5083685337 @default.
- W1500857601 creator A5084503754 @default.
- W1500857601 creator A5089639650 @default.
- W1500857601 creator A5056838461 @default.
- W1500857601 date "2014-07-01" @default.
- W1500857601 modified "2023-10-18" @default.
- W1500857601 title "Deep brain stimulation for Huntington's disease: long-term results of a prospective open-label study" @default.
- W1500857601 cites W1530651870 @default.
- W1500857601 cites W1968164001 @default.
- W1500857601 cites W1969468057 @default.
- W1500857601 cites W1973580591 @default.
- W1500857601 cites W1973688469 @default.
- W1500857601 cites W1987159715 @default.
- W1500857601 cites W1988679538 @default.
- W1500857601 cites W1996074434 @default.
- W1500857601 cites W2002838751 @default.
- W1500857601 cites W2003188335 @default.
- W1500857601 cites W2008042887 @default.
- W1500857601 cites W2008127853 @default.
- W1500857601 cites W2009589308 @default.
- W1500857601 cites W2014670291 @default.
- W1500857601 cites W2014941383 @default.
- W1500857601 cites W2020503995 @default.
- W1500857601 cites W2031684693 @default.
- W1500857601 cites W2032057552 @default.
- W1500857601 cites W2054968464 @default.
- W1500857601 cites W2055592992 @default.
- W1500857601 cites W2055962836 @default.
- W1500857601 cites W2061273629 @default.
- W1500857601 cites W2065500745 @default.
- W1500857601 cites W2070994934 @default.
- W1500857601 cites W2081443882 @default.
- W1500857601 cites W2082056883 @default.
- W1500857601 cites W2085590824 @default.
- W1500857601 cites W2089306952 @default.
- W1500857601 cites W2092789180 @default.
- W1500857601 cites W2102571676 @default.
- W1500857601 cites W2110915363 @default.
- W1500857601 cites W2114350861 @default.
- W1500857601 cites W2117640222 @default.
- W1500857601 cites W2118546680 @default.
- W1500857601 cites W2121178843 @default.
- W1500857601 cites W2130446748 @default.
- W1500857601 cites W2149201363 @default.
- W1500857601 cites W2164290214 @default.
- W1500857601 cites W2606710341 @default.
- W1500857601 cites W4230475322 @default.
- W1500857601 doi "https://doi.org/10.3171/2014.2.jns131722" @default.
- W1500857601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24702329" @default.
- W1500857601 hasPublicationYear "2014" @default.
- W1500857601 type Work @default.
- W1500857601 sameAs 1500857601 @default.
- W1500857601 citedByCount "73" @default.
- W1500857601 countsByYear W15008576012014 @default.
- W1500857601 countsByYear W15008576012015 @default.
- W1500857601 countsByYear W15008576012016 @default.
- W1500857601 countsByYear W15008576012017 @default.
- W1500857601 countsByYear W15008576012018 @default.
- W1500857601 countsByYear W15008576012019 @default.
- W1500857601 countsByYear W15008576012020 @default.
- W1500857601 countsByYear W15008576012021 @default.
- W1500857601 countsByYear W15008576012022 @default.
- W1500857601 countsByYear W15008576012023 @default.
- W1500857601 crossrefType "journal-article" @default.
- W1500857601 hasAuthorship W1500857601A5014176161 @default.
- W1500857601 hasAuthorship W1500857601A5016425817 @default.
- W1500857601 hasAuthorship W1500857601A5045189387 @default.
- W1500857601 hasAuthorship W1500857601A5045972001 @default.
- W1500857601 hasAuthorship W1500857601A5047553528 @default.
- W1500857601 hasAuthorship W1500857601A5055157209 @default.
- W1500857601 hasAuthorship W1500857601A5056838461 @default.
- W1500857601 hasAuthorship W1500857601A5060770453 @default.
- W1500857601 hasAuthorship W1500857601A5069054328 @default.
- W1500857601 hasAuthorship W1500857601A5077802711 @default.
- W1500857601 hasAuthorship W1500857601A5083685337 @default.
- W1500857601 hasAuthorship W1500857601A5084503754 @default.
- W1500857601 hasAuthorship W1500857601A5089639650 @default.
- W1500857601 hasConcept C118552586 @default.
- W1500857601 hasConcept C126322002 @default.
- W1500857601 hasConcept C188816634 @default.
- W1500857601 hasConcept C2778261627 @default.
- W1500857601 hasConcept C2778542668 @default.
- W1500857601 hasConcept C2778559928 @default.
- W1500857601 hasConcept C2778868616 @default.
- W1500857601 hasConcept C2779134260 @default.
- W1500857601 hasConcept C2779734285 @default.
- W1500857601 hasConcept C2780647506 @default.