FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1500860248> ?p ?o ?g. }

• W1500860248 endingPage "1483" @default.
• W1500860248 startingPage "1475" @default.
• W1500860248 abstract "The adult mammalian central nervous system displays limited reinnervation and recovery from trauma. However, during development, post-lesion plasticity may generate alternative paths, thus providing models to investigate reinnervation and repair. After unilateral transection of the neonatal rat olivocerebellar path (pedunculotomy), axons from the remaining inferior olive reinnervate the denervated hemicerebellum. Unfortunately, reinnervation to the cerebellar hemisphere is incomplete; therefore, its capacity to mediate hemispheric function (navigation) is unknown. We studied sensorimotor control and spatial cognition of rats with and without transcommissural reinnervation using simple (bridge and ladder) and complex (wire) locomotion tests and the Morris water maze (hidden, probe and cued paradigms). Although pedunculotomized animals completed locomotory tasks more slowly than controls, all groups performed equally in the cued maze, indicating that lesioned animals could orientate to and reach the platform. In animals pedunculotomized on day 3 (Px3), which develop olivocerebellar reinnervation, final spatial knowledge was as good as controls, although they learned more erratically, failing to retain all information from one day to the next. By contrast, animals pedunculotomized on day 11 (Px11), which do not develop reinnervation, did not learn the task, taking less direct routes and more time to reach the platform than controls. In the probe test, control and Px3, but not Px11, animals swam directly to the remembered location. Furthermore, the amount of transcommissural reinnervation to the denervated hemisphere correlated directly with spatial performance. These results show that transcommissural olivocerebellar reinnervation is associated with spatial learning, i.e. even partial circuit repair confers significant functional benefit." @default.
• W1500860248 created "2016-06-24" @default.
• W1500860248 creator A5037026312 @default.
• W1500860248 creator A5057938344 @default.
• W1500860248 creator A5076369054 @default.
• W1500860248 date "2007-04-05" @default.
• W1500860248 modified "2023-09-27" @default.
• W1500860248 title "Developmental neural plasticity and its cognitive benefits: olivocerebellar reinnervation compensates for spatial function in the cerebellum" @default.
• W1500860248 cites W1234403620 @default.
• W1500860248 cites W1482711476 @default.
• W1500860248 cites W1496914000 @default.
• W1500860248 cites W1527353552 @default.
• W1500860248 cites W1531847695 @default.
• W1500860248 cites W1817027815 @default.
• W1500860248 cites W1963801676 @default.
• W1500860248 cites W1965022353 @default.
• W1500860248 cites W1967516106 @default.
• W1500860248 cites W1970015182 @default.
• W1500860248 cites W1971615126 @default.
• W1500860248 cites W1973772115 @default.
• W1500860248 cites W1975858840 @default.
• W1500860248 cites W1978643044 @default.
• W1500860248 cites W1982509278 @default.
• W1500860248 cites W1986330166 @default.
• W1500860248 cites W1987193696 @default.
• W1500860248 cites W1989226479 @default.
• W1500860248 cites W1991235255 @default.
• W1500860248 cites W1997437358 @default.
• W1500860248 cites W1999185549 @default.
• W1500860248 cites W2001324648 @default.
• W1500860248 cites W2007663928 @default.
• W1500860248 cites W2013802844 @default.
• W1500860248 cites W2014022149 @default.
• W1500860248 cites W2021146631 @default.
• W1500860248 cites W2023057624 @default.
• W1500860248 cites W2031116443 @default.
• W1500860248 cites W2034210039 @default.
• W1500860248 cites W2042912602 @default.
• W1500860248 cites W2044270044 @default.
• W1500860248 cites W2045867582 @default.
• W1500860248 cites W2048622288 @default.
• W1500860248 cites W2049028163 @default.
• W1500860248 cites W2052208984 @default.
• W1500860248 cites W2062082744 @default.
• W1500860248 cites W2062256435 @default.
• W1500860248 cites W2066073499 @default.
• W1500860248 cites W2070002886 @default.
• W1500860248 cites W2073325493 @default.
• W1500860248 cites W2083825172 @default.
• W1500860248 cites W2089197692 @default.
• W1500860248 cites W2105426844 @default.
• W1500860248 cites W2107751454 @default.
• W1500860248 cites W2109550978 @default.
• W1500860248 cites W2112559667 @default.
• W1500860248 cites W2131856835 @default.
• W1500860248 cites W2132631855 @default.
• W1500860248 cites W2133958059 @default.
• W1500860248 cites W2141145966 @default.
• W1500860248 cites W2158782226 @default.
• W1500860248 cites W2169473035 @default.
• W1500860248 cites W2172157926 @default.
• W1500860248 cites W2323252032 @default.
• W1500860248 cites W2496127436 @default.
• W1500860248 cites W2743059607 @default.
• W1500860248 cites W4245723312 @default.
• W1500860248 cites W4247251460 @default.
• W1500860248 cites W4255224241 @default.
• W1500860248 doi "https://doi.org/10.1111/j.1460-9568.2007.05410.x" @default.
• W1500860248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17425573" @default.
• W1500860248 hasPublicationYear "2007" @default.
• W1500860248 type Work @default.
• W1500860248 sameAs 1500860248 @default.
• W1500860248 citedByCount "15" @default.
• W1500860248 countsByYear W15008602482012 @default.
• W1500860248 countsByYear W15008602482013 @default.
• W1500860248 countsByYear W15008602482014 @default.
• W1500860248 countsByYear W15008602482020 @default.
• W1500860248 countsByYear W15008602482021 @default.
• W1500860248 countsByYear W15008602482022 @default.
• W1500860248 crossrefType "journal-article" @default.
• W1500860248 hasAuthorship W1500860248A5037026312 @default.
• W1500860248 hasAuthorship W1500860248A5057938344 @default.
• W1500860248 hasAuthorship W1500860248A5076369054 @default.
• W1500860248 hasConcept C15744967 @default.
• W1500860248 hasConcept C169760540 @default.
• W1500860248 hasConcept C180747234 @default.
• W1500860248 hasConcept C2779649809 @default.
• W1500860248 hasConcept C2779652256 @default.
• W1500860248 hasConcept C47611674 @default.
• W1500860248 hasConcept C83195618 @default.
• W1500860248 hasConcept C94487597 @default.
• W1500860248 hasConceptScore W1500860248C15744967 @default.
• W1500860248 hasConceptScore W1500860248C169760540 @default.
• W1500860248 hasConceptScore W1500860248C180747234 @default.
• W1500860248 hasConceptScore W1500860248C2779649809 @default.
• W1500860248 hasConceptScore W1500860248C2779652256 @default.
• W1500860248 hasConceptScore W1500860248C47611674 @default.
• W1500860248 hasConceptScore W1500860248C83195618 @default.

• next