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• W1500927429 abstract "Mature B-cell acute lymphocytic leukemia (B-ALL) was recognized in the mid-1970s as a rare subtype (2–4%) of childhood ALL cases (1). This disease appeared to be more aggressive than other leukemias, often with lymphomatous tumors and poor response to treatment. Leukemic cells were characterized by L3 morphology according to the French—American— British (FAB) classification and by the expression of monoclonal surface immunoglobulin (SIg). A relationship between Burkitt’s lymphoma and L3 leukemia was evoked early. It appeared that these diseases were in fact different forms of the same disease (B-cell disease): the tumoral cells had the same cytologic and immunologic features and displayed the same specific nonrandom chromosomal translocations, t(8; 14) (q24; q32), t(2; 8) (p12; q24), and t(8; 22) (q24; q 11). The disease is also characterized by a high proliferation rate and a short doubling time, by a great propensity to disseminate and invade organ systems, in particular the central nervous system (CNS), by a poor response to conventional therapy, and by very early relapses." @default.
• W1500927429 created "2016-06-24" @default.
• W1500927429 creator A5041052627 @default.
• W1500927429 date "2003-01-01" @default.
• W1500927429 modified "2023-09-23" @default.
• W1500927429 title "Treatment of B-Cell Acute Lymphoblastic Leukemia" @default.
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• W1500927429 doi "https://doi.org/10.1007/978-1-59259-307-1_15" @default.
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