Matches in SemOpenAlex for { <https://semopenalex.org/work/W1501149738> ?p ?o ?g. }
- W1501149738 endingPage "623" @default.
- W1501149738 startingPage "616" @default.
- W1501149738 abstract "Abstract Immunotherapy for solid cancers, such as oesophageal adenocarcinoma (OAC), is generally hampered by an unfavourable immunological tumour microenvironment. This prompted us to investigate the nature of the OAC environment. Biopsies of tumour and normal control tissues were collected from 17 OAC patients, and investigated using fluorescent immunohistochemistry (IHC) for the expression of cyclooxygenase‐2 (COX‐2), vascular endothelial growth factor (VEGF), transforming growth factor‐β, indoleamine 2–3 dioxygenase, CXCL3 and CXCR1, and for measuring a panel of cytokines by cytometric bead array (CBA), and for Granzyme B (GrB), Perforin and PI9 detection by semi‐quantitative PCR (QPCR). IHC showed that expression of all the above‐mentioned factors is upregulated in 80–93% of the tumours. By QPCR, the cytokine interleukin (IL)‐8 was significantly upregulated in tumour samples ( P < 0.05). IL‐6, IL‐10, GrB and Perforin did not show any significant difference between normal and tumour samples, whereas PI9 levels were significantly higher in normal when compared with the tumour samples. CBA confirmed upregulation of IL‐8 and show upregulation of IL‐1β in the tumours ( P < 0.05). Regarding IL‐6 and interferon (IFN)‐γ, no significant differences were observed between normal and tumour tissues. The OAC microenvironment is characterized by a lack of cytokines and factors that normally would enhance anti‐cancer responses, such as IFN‐γ and GrB, and by a high expression of several immuno‐suppressive factors, such as COX‐2, VEGF and IL‐8. For future improvement of treatment efficacy of OAC patients, it will be of importance to combine immunotherapy with immune‐modulating agents." @default.
- W1501149738 created "2016-06-24" @default.
- W1501149738 creator A5002257991 @default.
- W1501149738 creator A5018941906 @default.
- W1501149738 creator A5024990785 @default.
- W1501149738 creator A5036718036 @default.
- W1501149738 creator A5039044781 @default.
- W1501149738 creator A5052571347 @default.
- W1501149738 creator A5079433293 @default.
- W1501149738 creator A5079898834 @default.
- W1501149738 date "2008-10-29" @default.
- W1501149738 modified "2023-10-10" @default.
- W1501149738 title "Expression Pattern of Immune Suppressive Cytokines and Growth Factors in Oesophageal Adenocarcinoma Reveal a Tumour Immune Escape-promoting Microenvironment" @default.
- W1501149738 cites W1534491890 @default.
- W1501149738 cites W193511566 @default.
- W1501149738 cites W193748226 @default.
- W1501149738 cites W1983378719 @default.
- W1501149738 cites W1984484036 @default.
- W1501149738 cites W1986196430 @default.
- W1501149738 cites W2006994017 @default.
- W1501149738 cites W2020189113 @default.
- W1501149738 cites W2022430924 @default.
- W1501149738 cites W2056308227 @default.
- W1501149738 cites W2062028241 @default.
- W1501149738 cites W2063307907 @default.
- W1501149738 cites W2069518622 @default.
- W1501149738 cites W2069642304 @default.
- W1501149738 cites W2072942746 @default.
- W1501149738 cites W2084280165 @default.
- W1501149738 cites W2088571368 @default.
- W1501149738 cites W2099503467 @default.
- W1501149738 cites W2106074488 @default.
- W1501149738 cites W2108244474 @default.
- W1501149738 cites W2116554142 @default.
- W1501149738 cites W2121479816 @default.
- W1501149738 cites W2122452468 @default.
- W1501149738 cites W2124208155 @default.
- W1501149738 cites W2126258731 @default.
- W1501149738 cites W2140432305 @default.
- W1501149738 cites W2141890248 @default.
- W1501149738 cites W2152857351 @default.
- W1501149738 cites W2156106286 @default.
- W1501149738 cites W2160064816 @default.
- W1501149738 cites W2162819001 @default.
- W1501149738 cites W2164948224 @default.
- W1501149738 cites W2170172676 @default.
- W1501149738 cites W2170202550 @default.
- W1501149738 cites W2185301137 @default.
- W1501149738 cites W4313333674 @default.
- W1501149738 doi "https://doi.org/10.1111/j.1365-3083.2008.02183.x" @default.
- W1501149738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19055699" @default.
- W1501149738 hasPublicationYear "2008" @default.
- W1501149738 type Work @default.
- W1501149738 sameAs 1501149738 @default.
- W1501149738 citedByCount "26" @default.
- W1501149738 countsByYear W15011497382012 @default.
- W1501149738 countsByYear W15011497382013 @default.
- W1501149738 countsByYear W15011497382014 @default.
- W1501149738 countsByYear W15011497382015 @default.
- W1501149738 countsByYear W15011497382016 @default.
- W1501149738 countsByYear W15011497382017 @default.
- W1501149738 countsByYear W15011497382019 @default.
- W1501149738 countsByYear W15011497382020 @default.
- W1501149738 countsByYear W15011497382021 @default.
- W1501149738 countsByYear W15011497382022 @default.
- W1501149738 crossrefType "journal-article" @default.
- W1501149738 hasAuthorship W1501149738A5002257991 @default.
- W1501149738 hasAuthorship W1501149738A5018941906 @default.
- W1501149738 hasAuthorship W1501149738A5024990785 @default.
- W1501149738 hasAuthorship W1501149738A5036718036 @default.
- W1501149738 hasAuthorship W1501149738A5039044781 @default.
- W1501149738 hasAuthorship W1501149738A5052571347 @default.
- W1501149738 hasAuthorship W1501149738A5079433293 @default.
- W1501149738 hasAuthorship W1501149738A5079898834 @default.
- W1501149738 hasBestOaLocation W15011497381 @default.
- W1501149738 hasConcept C104317684 @default.
- W1501149738 hasConcept C118131993 @default.
- W1501149738 hasConcept C127561419 @default.
- W1501149738 hasConcept C134018914 @default.
- W1501149738 hasConcept C167672396 @default.
- W1501149738 hasConcept C167734588 @default.
- W1501149738 hasConcept C203014093 @default.
- W1501149738 hasConcept C204232928 @default.
- W1501149738 hasConcept C2776062744 @default.
- W1501149738 hasConcept C2776090121 @default.
- W1501149738 hasConcept C2776107976 @default.
- W1501149738 hasConcept C2776178377 @default.
- W1501149738 hasConcept C2777025900 @default.
- W1501149738 hasConcept C2777701055 @default.
- W1501149738 hasConcept C2778690821 @default.
- W1501149738 hasConcept C2780380082 @default.
- W1501149738 hasConcept C2780394083 @default.
- W1501149738 hasConcept C3018558359 @default.
- W1501149738 hasConcept C502942594 @default.
- W1501149738 hasConcept C55493867 @default.
- W1501149738 hasConcept C86803240 @default.
- W1501149738 hasConcept C8891405 @default.
- W1501149738 hasConceptScore W1501149738C104317684 @default.