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• W1501149743 abstract "Abstract Poly(ethylene oxide) (PEO)-carboxyvinylpolymer (CP) solid dispersions containing phenacetin (PHE) were prepared using water/ethanol mixture as a solvent. The solvent composition and the release behavior of PHE from the solid dispersions were studied. It was found that the mixture of water/ethanol (1/1, v/v) was useful for the solvent to prepare solid dispersions. The release rate of PHE from the PHE-PEO system was larger than that from PHE powder. In the PHE-CP system, almost the same release rate was observed as PHE powder. The release rate from the PHE-PEO-CP system obviously varied depending on the PEO/CP ratio and reached the minimum level at the PEO/CP ratio of 1/1 (w/w). FT-IR spectra suggested the interaction of hydrogen bonding between PEO and CP. These results indicate that it is feasible to control the medicine release from the solid dispersions by using PEO and CP." @default.
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• W1501149743 date "1998-05-01" @default.
• W1501149743 modified "2023-09-26" @default.
• W1501149743 title "Control of medicine release from solid dispersion through poly(ethylene oxide)-carboxyvinylpolymer interaction1This article is Part X of ‘Application of the Solid Dispersion Method to the Controlled Release of Medicine’. Part IX: Ozeki, T., Yuasa, H., Kanaya, Y., 1997. Int. J. Pharmaceut., 155, 209–217.1" @default.
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• W1501149743 doi "https://doi.org/10.1016/s0378-5173(98)00011-8" @default.
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