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• W1501213952 abstract "Objective: toevaluate Metallo-betalactamase (MBL) inhibitory effect and antimicrobial activity against Acinetobacter baumannii of methanolic and aqueous extracts of Terminaliachebula dried fruits. Methods: effect of EDTA (Ethylenediaminetetraacetic acid), methanolic and aqueous extracts of dried fruits of T. chebula on Metallo-betalactamase activity was studied in vitro by using cephaloridin asasubstrate. The degree of inhibition was determined byIC 50 and the antimicrobial activities of both extracts against Acinetobacter baumannii were qualitatively and quantitatively assessed by the presence or absence of inhibition zones, MIC and MBC values. Results: EDTA, methanolic and aqueous extracts inhibit metallo-betalactamases activity withIC 50 (3.98 mM, 18.45 and 19.68µg/ml), respectively. Polyphenols in aqueousand methanolic extracts are 513.094±3.061 and 496±2.856 µg GAE/mg, respectively. Conclusion: These results indicate that both extracts of T. chebula are rich in polyphenols and have a strong inhibitory effect on metallo-betalactamases in a competitive manner compared to EDTA. In addition, both extracts of T. chebula were also screened for their remarkable antibacterial and bactericidal activity against Acinetobacter baumannii confirmed by low minimum inhibitory and bactericidal concentration (MIC and MBC)." @default.
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• W1501213952 date "2014-09-01" @default.
• W1501213952 modified "2023-09-27" @default.
• W1501213952 title "THE INHIBITORY EFFECT OF METHANOLIC AND AQUEOUS EXTRACTS OF TERMINALIA CHEBULA DRIED FRUITS ON METALLOBETALACTAMASES OF ACINETOBACTER BAUMANNII" @default.
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