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- W1501265571 abstract "Studies have been reported upon the endometriotropic responses of 23 patients with functional irregularities of uterine bleeding during 99 of 117 cyclic series of therapy with progesterone alone or combined with estrogens. During 30 cycles of 4 of these patients, and during 10 cycles of an additional group of 3 patients, similarly treated, urinary titers of sodium pregnandiol glucuronide were determined. The endometriotropic data warrant the conclusion that crystalline progesterone, when administered intramuscularly in oil to women with functional irregularities of uterine bleeding, is inefficiently utilized. Six of the 7 patients studied were also unable to utilize efficiently their intrinsic progestin despite the existence of evidence that it was being metabolized normally. The intramuscular administration of crystalline progesterone to these patients resulted not only in no increases in their urinary titers of the pregnandiol-complex but also in apparent decreases. These observations suggest that incomplete metabolism occurred. Some of the various factors which may influence the metabolism and utilization of progesterone are discussed." @default.
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- W1501265571 date "1939-10-01" @default.
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- W1501265571 title "The metabolism and utilization of progesterone given intramuscularly to women" @default.
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- W1501265571 doi "https://doi.org/10.1016/s0002-9378(39)90349-2" @default.
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