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- W1501358984 abstract "Abstract The introduction of a retrovirus vector expressing p210bcr-abl (P210) into the human factor-dependent cell line M07E resulted in the rapid outgrowth of factor-independent cells. Early after infection, four factor-independent clones were isolated and analyzed in greater detail along with mass populations obtained from separate infections. High levels of P210 tyrosine kinase activity were measured in the factor- independent cells. The mass populations and three of the four clones remained responsive to exogenous growth factors. Concentrated conditioned media isolated from the factor-independent populations and from all clones contained biologically active granulocyte-macrophage colony-stimulating factor (GM-CSF); interleukin-3 (IL-3) was detected at low levels in the mass population and in two of the clones. Neutralizing antibodies to IL-3, GM-CSF, and mast cell growth factor inhibited proliferation of the factor responsive clones by 60% to 90%. These results indicate that the growth autonomy of the P210-expressing M07E cells was acquired via an autocrine mechanism. In addition to factor-independent growth, P210-expressing M07E cells readily acquired a more mature megakaryocytic phenotype compared with control M07E cells. These data provide experimental evidence that expression of P210 tyrosine kinase in human hematopoietic cells induced growth factor secretion resulting in a pleiotropic effect on growth factor dependence and differentiation." @default.
- W1501358984 created "2016-06-24" @default.
- W1501358984 creator A5003550639 @default.
- W1501358984 creator A5086796244 @default.
- W1501358984 creator A5090356933 @default.
- W1501358984 date "1994-03-15" @default.
- W1501358984 modified "2023-10-11" @default.
- W1501358984 title "Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism" @default.
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- W1501358984 doi "https://doi.org/10.1182/blood.v83.6.1575.1575" @default.
- W1501358984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8123848" @default.
- W1501358984 hasPublicationYear "1994" @default.
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