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• W1501400298 endingPage "2070" @default.
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• W1501400298 abstract "To analyze whether the presence of anti-HBs in liver transplant recipients is effective in preventing HBV infection.Twenty-three patients receiving anti-HBc positive liver were studied. Nine recipients were anti-HBc positive as a result of previous HBV infection. Of them, one also received HBV vaccine during the pre-liver transplantation period. Fourteen recipients were anti-HBs positive due to HBV vaccine administered during the pre-transplant period. Liver biopsy was obtained in 10/14 anti-HBc negative/anti-HBs positive recipients and in 4/9 anti-HBc positive recipients.After a mean follow-up period of 46 months, 1 recipient with protective serum anti-HBs levels developed de novo HBV infection as a consequence of immune escape HBV mutants. Among the 14 vaccinated anti-HBc negative/anti-HBs positive recipients, 1/10 patients with available liver biopsy (10%) had liver HBV-DNA at 13 mo post-liver transplantation without serum viral markers and did not develop de novo HBV infection. The vaccinated anti-HBc positive recipient without HBV vaccine response was HBV-DNA positive in serum and liver, viral DNA was continuously negative in the following tests, so a spontaneous seroconversion was diagnosed.The presence of anti-HBs as a result of HBV vaccine or past HBV infection seems to be effective at protecting patients receiving livers from anti-HBc positive donors. However, the emergence of immune escape HBV mutants, which can evade the anti-HBs protection, should be considered as a risk of HBV infection." @default.
• W1501400298 created "2016-06-24" @default.
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• W1501400298 date "2006-01-01" @default.
• W1501400298 modified "2023-10-06" @default.
• W1501400298 title "Prevention of de novo HBV infection by the presence of anti-HBs in transplanted patients receiving core antibody-positive livers" @default.
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• W1501400298 doi "https://doi.org/10.3748/wjg.v12.i13.2070" @default.
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