Matches in SemOpenAlex for { <https://semopenalex.org/work/W1501414201> ?p ?o ?g. }
- W1501414201 endingPage "1886" @default.
- W1501414201 startingPage "1877" @default.
- W1501414201 abstract "The blood-brain barrier (BBB) is located within a unique anatomic interface and has functional ramifications to most of the brain and blood cells. In the past, the BBB was considered a pharmacokinetic impediment to antiepileptic drug penetration into the brain; nowadays it is becoming increasingly evident that targeting of the damaged or dysfunctional BBB may represent a therapeutic approach to reduce seizure burden. Several studies have investigated the mechanisms linking the onset and sustainment of seizures to BBB dysfunction. These studies have shown that the BBB is at the crossroad of a multifactorial pathophysiologic process that involves changes in brain milieu, altered neuroglial physiology, development of brain inflammation, leukocyte-endothelial interactions, faulty angiogenesis, and hemodynamic changes leading to energy mismatch. A number of knowledge gaps, conflicting points of view, and discordance between clinical and experimental data currently characterize this field of neuroscience. As more pieces are added to this puzzle, it is apparent that each mechanism needs to be validated in an appropriate clinical context. We now offer a BBB-centric view of seizure disorders, linking several aspects of seizures and epilepsy physiopathology to BBB dysfunction. We have reviewed the therapeutic, antiseizure effect of drugs that promote BBB repair. We also present BBB neuroimaging as a tool to correlate BBB restoration to seizure mitigation. Add-on cerebrovascular drug could be of efficacy in reducing seizure burden when used in association with neuronal antiepileptic drugs." @default.
- W1501414201 created "2016-06-24" @default.
- W1501414201 creator A5008413693 @default.
- W1501414201 creator A5022149512 @default.
- W1501414201 creator A5049237819 @default.
- W1501414201 creator A5072148725 @default.
- W1501414201 date "2012-08-20" @default.
- W1501414201 modified "2023-10-13" @default.
- W1501414201 title "Blood-brain barrier dysfunction and epilepsy: Pathophysiologic role and therapeutic approaches" @default.
- W1501414201 cites W127714186 @default.
- W1501414201 cites W1520207918 @default.
- W1501414201 cites W1552018280 @default.
- W1501414201 cites W1778992185 @default.
- W1501414201 cites W1849249330 @default.
- W1501414201 cites W1953681520 @default.
- W1501414201 cites W1963624465 @default.
- W1501414201 cites W1966697781 @default.
- W1501414201 cites W1971775352 @default.
- W1501414201 cites W1974437785 @default.
- W1501414201 cites W1976582395 @default.
- W1501414201 cites W1977291679 @default.
- W1501414201 cites W1977477970 @default.
- W1501414201 cites W1979848898 @default.
- W1501414201 cites W1988806347 @default.
- W1501414201 cites W1992758695 @default.
- W1501414201 cites W2008068294 @default.
- W1501414201 cites W2020189206 @default.
- W1501414201 cites W2022120753 @default.
- W1501414201 cites W2022307232 @default.
- W1501414201 cites W2022796522 @default.
- W1501414201 cites W2022981588 @default.
- W1501414201 cites W2026609084 @default.
- W1501414201 cites W2031120775 @default.
- W1501414201 cites W2031487565 @default.
- W1501414201 cites W2033104744 @default.
- W1501414201 cites W2034058614 @default.
- W1501414201 cites W2034768236 @default.
- W1501414201 cites W2039948712 @default.
- W1501414201 cites W2040958998 @default.
- W1501414201 cites W2042517808 @default.
- W1501414201 cites W2046221727 @default.
- W1501414201 cites W2047841272 @default.
- W1501414201 cites W2048274371 @default.
- W1501414201 cites W2056046616 @default.
- W1501414201 cites W2056326370 @default.
- W1501414201 cites W2059282388 @default.
- W1501414201 cites W2059491535 @default.
- W1501414201 cites W2060215608 @default.
- W1501414201 cites W2066284829 @default.
- W1501414201 cites W2067556881 @default.
- W1501414201 cites W2068034417 @default.
- W1501414201 cites W2068929498 @default.
- W1501414201 cites W2070833420 @default.
- W1501414201 cites W2078412655 @default.
- W1501414201 cites W2080938528 @default.
- W1501414201 cites W2082634781 @default.
- W1501414201 cites W2087982685 @default.
- W1501414201 cites W2088900547 @default.
- W1501414201 cites W2089970255 @default.
- W1501414201 cites W2093801694 @default.
- W1501414201 cites W2098477576 @default.
- W1501414201 cites W2102561151 @default.
- W1501414201 cites W2103824935 @default.
- W1501414201 cites W2104931119 @default.
- W1501414201 cites W2106013244 @default.
- W1501414201 cites W2107117452 @default.
- W1501414201 cites W2107616947 @default.
- W1501414201 cites W2108170307 @default.
- W1501414201 cites W2109644106 @default.
- W1501414201 cites W2110399898 @default.
- W1501414201 cites W2112937635 @default.
- W1501414201 cites W2117848707 @default.
- W1501414201 cites W2126592491 @default.
- W1501414201 cites W2127587930 @default.
- W1501414201 cites W2129658473 @default.
- W1501414201 cites W2130201468 @default.
- W1501414201 cites W2134389315 @default.
- W1501414201 cites W2140316884 @default.
- W1501414201 cites W2144003555 @default.
- W1501414201 cites W2148547181 @default.
- W1501414201 cites W2150163312 @default.
- W1501414201 cites W2159252521 @default.
- W1501414201 cites W2159821105 @default.
- W1501414201 cites W2163522951 @default.
- W1501414201 cites W2168030974 @default.
- W1501414201 cites W2171255613 @default.
- W1501414201 doi "https://doi.org/10.1111/j.1528-1167.2012.03637.x" @default.
- W1501414201 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4842020" @default.
- W1501414201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22905812" @default.
- W1501414201 hasPublicationYear "2012" @default.
- W1501414201 type Work @default.
- W1501414201 sameAs 1501414201 @default.
- W1501414201 citedByCount "193" @default.
- W1501414201 countsByYear W15014142012012 @default.
- W1501414201 countsByYear W15014142012013 @default.
- W1501414201 countsByYear W15014142012014 @default.
- W1501414201 countsByYear W15014142012015 @default.
- W1501414201 countsByYear W15014142012016 @default.