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- W1501473876 abstract "We demonstrate here that EL4–6.1 cells, a mouse thymoma that expresses high levels of membrane interleukin (IL)-1 receptors, produce IL-1 beta as an autocrine regulatory factor. Endogenous IL-1 beta sustains both proliferation and apoptosis: during the exponential phase, it mainly promotes proliferation, while during the plateau phase of cell growth, it induces death by apoptosis. Additionally, we show that exogenous IL-1 beta added to EL4–6.1 cells in lag phase induces apoptosis in a portion of the cells and proliferation in the remaining cells. Therefore, IL-1 beta can exert two completely opposite effects on a single cell type, depending on the state of the target cell." @default.
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- W1501473876 date "1995-06-15" @default.
- W1501473876 modified "2023-10-06" @default.
- W1501473876 title "Autocrine interleukin-1 beta regulates both proliferation and apoptosis in EL4-6.1 thymoma cells" @default.
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- W1501473876 doi "https://doi.org/10.1182/blood.v85.12.3532.bloodjournal85123532" @default.
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