FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1501557580> ?p ?o ?g. }

• W1501557580 endingPage "5030" @default.
• W1501557580 startingPage "5025" @default.
• W1501557580 abstract "Oestradiol (E2) exerts critical homeostatic feedback effects upon gonadotropin‐releasing hormone (GnRH) neurons to maintain fertility. In the female, E2 has both negative and positive feedback actions to suppress and stimulate GnRH neuron activity at different times of the ovarian cycle. This review summarizes reported rapid E2 effects on native embryonic and adult GnRH neurons and attempts to put them into a physiological perspective. Oestrogen has been shown to rapidly modulate multiple processes in embryonic and adult GnRH neurons including intracellular calcium levels, electrical activity and specific second messenger pathways, as well as GnRH secretion itself. Evaluation of in vivo data suggests that there is no essential role for rapid E2 actions in the positive feedback mechanism but that they may comprise part of the negative feedback pathway. Adult GnRH neurons are only likely to be exposed to E2 from the gonads via the circulation with appropriate physiological E2 concentrations in the rodent being 10–50 p m for negative feedback ranging up to 400 p m for positive feedback. Although most studies to date have examined the effects of supraphysiological E2 levels on GnRH neurons, there is accumulating evidence that rapid E2 actions may have a physiological role in suppressing GnRH neuron activity." @default.
• W1501557580 created "2016-06-24" @default.
• W1501557580 creator A5052685703 @default.
• W1501557580 date "2009-10-30" @default.
• W1501557580 modified "2023-10-15" @default.
• W1501557580 title "Rapid actions of oestrogen on gonadotropin-releasing hormone neurons; from fantasy to physiology?" @default.
• W1501557580 cites W1969474756 @default.
• W1501557580 cites W1980519264 @default.
• W1501557580 cites W1982495479 @default.
• W1501557580 cites W1985323260 @default.
• W1501557580 cites W1988240151 @default.
• W1501557580 cites W1992481216 @default.
• W1501557580 cites W2006727096 @default.
• W1501557580 cites W2009302214 @default.
• W1501557580 cites W2012253186 @default.
• W1501557580 cites W2020665150 @default.
• W1501557580 cites W2024067647 @default.
• W1501557580 cites W2025673280 @default.
• W1501557580 cites W2037990673 @default.
• W1501557580 cites W2039698855 @default.
• W1501557580 cites W2039952305 @default.
• W1501557580 cites W2052104297 @default.
• W1501557580 cites W2052757541 @default.
• W1501557580 cites W2058002380 @default.
• W1501557580 cites W2065888308 @default.
• W1501557580 cites W2067030363 @default.
• W1501557580 cites W2067345204 @default.
• W1501557580 cites W2075291501 @default.
• W1501557580 cites W2075307470 @default.
• W1501557580 cites W2076127338 @default.
• W1501557580 cites W2080599802 @default.
• W1501557580 cites W2089315979 @default.
• W1501557580 cites W2095833455 @default.
• W1501557580 cites W2115195541 @default.
• W1501557580 cites W2115699651 @default.
• W1501557580 cites W2157861204 @default.
• W1501557580 cites W2158893781 @default.
• W1501557580 cites W2162755691 @default.
• W1501557580 cites W2163870236 @default.
• W1501557580 cites W2168918401 @default.
• W1501557580 cites W3023672242 @default.
• W1501557580 cites W4245385034 @default.
• W1501557580 cites W4246835056 @default.
• W1501557580 cites W4322703282 @default.
• W1501557580 doi "https://doi.org/10.1113/jphysiol.2009.179838" @default.
• W1501557580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2790245" @default.
• W1501557580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19687121" @default.
• W1501557580 hasPublicationYear "2009" @default.
• W1501557580 type Work @default.
• W1501557580 sameAs 1501557580 @default.
• W1501557580 citedByCount "42" @default.
• W1501557580 countsByYear W15015575802012 @default.
• W1501557580 countsByYear W15015575802013 @default.
• W1501557580 countsByYear W15015575802014 @default.
• W1501557580 countsByYear W15015575802015 @default.
• W1501557580 countsByYear W15015575802017 @default.
• W1501557580 countsByYear W15015575802018 @default.
• W1501557580 countsByYear W15015575802020 @default.
• W1501557580 countsByYear W15015575802021 @default.
• W1501557580 countsByYear W15015575802022 @default.
• W1501557580 countsByYear W15015575802023 @default.
• W1501557580 crossrefType "journal-article" @default.
• W1501557580 hasAuthorship W1501557580A5052685703 @default.
• W1501557580 hasBestOaLocation W15015575802 @default.
• W1501557580 hasConcept C119599485 @default.
• W1501557580 hasConcept C121332964 @default.
• W1501557580 hasConcept C126322002 @default.
• W1501557580 hasConcept C127413603 @default.
• W1501557580 hasConcept C134018914 @default.
• W1501557580 hasConcept C165801399 @default.
• W1501557580 hasConcept C169760540 @default.
• W1501557580 hasConcept C2778575703 @default.
• W1501557580 hasConcept C2778782382 @default.
• W1501557580 hasConcept C2778794669 @default.
• W1501557580 hasConcept C2778894405 @default.
• W1501557580 hasConcept C48207687 @default.
• W1501557580 hasConcept C62520636 @default.
• W1501557580 hasConcept C71315377 @default.
• W1501557580 hasConcept C71924100 @default.
• W1501557580 hasConcept C86803240 @default.
• W1501557580 hasConcept C93586867 @default.
• W1501557580 hasConceptScore W1501557580C119599485 @default.
• W1501557580 hasConceptScore W1501557580C121332964 @default.
• W1501557580 hasConceptScore W1501557580C126322002 @default.
• W1501557580 hasConceptScore W1501557580C127413603 @default.
• W1501557580 hasConceptScore W1501557580C134018914 @default.
• W1501557580 hasConceptScore W1501557580C165801399 @default.
• W1501557580 hasConceptScore W1501557580C169760540 @default.
• W1501557580 hasConceptScore W1501557580C2778575703 @default.
• W1501557580 hasConceptScore W1501557580C2778782382 @default.
• W1501557580 hasConceptScore W1501557580C2778794669 @default.
• W1501557580 hasConceptScore W1501557580C2778894405 @default.
• W1501557580 hasConceptScore W1501557580C48207687 @default.
• W1501557580 hasConceptScore W1501557580C62520636 @default.
• W1501557580 hasConceptScore W1501557580C71315377 @default.
• W1501557580 hasConceptScore W1501557580C71924100 @default.
• W1501557580 hasConceptScore W1501557580C86803240 @default.
• W1501557580 hasConceptScore W1501557580C93586867 @default.

• next