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• W1501607445 abstract "Aims . The polymorphisms of pro- and anti-inflammatory cytokines may be involved in type 2 diabetes (T2D) pathogenesis and its complications. Methods . We investigated in 102 T2D patients the association of the cytokine polymorphisms in the TNF- α , IL-10, IL-6, TGF- β 1, and IFN- γ genes with the T2D microvascular complications and comorbidities (hypertension, dyslipidemia, and obesity). Cytokine genotypes were determined by PCR using Cytokine Genotyping Tray kit. Results. Diabetic retinopathy was associated with GG genotype and G allele in TGF- β 1 codon 25C/G polymorphism (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.004</mml:mn></mml:math>and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.018</mml:mn></mml:math>) and the nephropathy was associated the lower frequency of GG genotype in IL-10 -1082G/A polymorphism (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.049</mml:mn></mml:math>). Hypertension was associated with the CC genotype and C allele for IL-10 -592C/A polymorphism (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.013</mml:mn></mml:math>and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.009</mml:mn></mml:math>) and higher frequencies of T (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.047</mml:mn></mml:math>) and C (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.033</mml:mn></mml:math>) alleles of the TGF- β 1 codon 10T/C and IL-10 -819T/C polymorphisms, respectively. The TGF- β 1 codon 10T/C polymorphism was associated with the BMI groups (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.026</mml:mn></mml:math>): the CC genotype was more frequent in the group with BMI < 25 Kg/m 2 , while the TC genotype was more frequent in the group with BMI = 30 Kg/m 2 . Conclusions . Our findings suggest that TGF- β 1 and IL-10 polymorphisms are involved in complications and comorbidities in T2D patients." @default.
• W1501607445 created "2016-06-24" @default.
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• W1501607445 date "2015-01-01" @default.
• W1501607445 modified "2023-10-14" @default.
• W1501607445 title "Association of a Large Panel of Cytokine Gene Polymorphisms with Complications and Comorbidities in Type 2 Diabetes Patients" @default.
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• W1501607445 doi "https://doi.org/10.1155/2015/605965" @default.
• W1501607445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4438177" @default.
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