Matches in SemOpenAlex for { <https://semopenalex.org/work/W1501636063> ?p ?o ?g. }
- W1501636063 endingPage "33" @default.
- W1501636063 startingPage "1" @default.
- W1501636063 abstract "The N-methyl-D-aspartic acid (NMDA)-sensitive subclass of brain excitatory amino acid receptors is supposed to be a receptor-ionophore complex consisting of at least 3 different major domains including an NMDA recognition site, glycine (Gly) recognition site and ion channel site. Biochemical labeling of the NMDA domain using [3H]L-glutamic acid (Glu) as a radioactive ligand often meets with several critical methodological pitfalls and artifacts that cause a serious misinterpretation of the results. Treatment of brain synaptic membranes with a low concentration of Triton X-100 induces a marked disclosure of [3H]Glu binding sensitive to displacement by NMDA with a concomitant removal of other several membranous constituents with relatively high affinity for the neuroactive amino acid. The NMDA site is also radiolabeled by the competitive antagonist (+/-)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid that reveals possible heterogeneity of the site. The Gly domain is sensitive to D-serine and D-alanine but insensitive to strychnine, and this domain seems to be absolutely required for an opening of the NMDA channels by agonists. The ionophore domain is radiolabeled by a non-competitive type of NMDA antagonist that is only able to bind to the open but not closed channels. The binding of these allosteric antagonists is markedly potentiated by NMDA agonists in a manner sensitive to antagonism by isosteric antagonists in brain synaptic membranes and additionally enhanced by further inclusion of Gly agonists through the Gly domain. Furthermore, physiological and biochemical responses mediated by the NMDA receptor complex are invariably potentiated by several endogenous polyamines, suggesting a novel polyamine site within the complex. At any rate, activation of the NMDA receptor complex results in a marked influx of Ca2+ as well as Na+ ions, which subsequently induces numerous intracellular metabolic alterations that could be associated with neuronal plasticity or excitotoxicity. Therefore, any isosteric and allosteric antagonists would be of great benefit for the therapy and treatment of neurodegenerative disorders with a risk of impairing the acquisition and formation process of memories." @default.
- W1501636063 created "2016-06-24" @default.
- W1501636063 creator A5005404495 @default.
- W1501636063 creator A5083134882 @default.
- W1501636063 date "1991-02-01" @default.
- W1501636063 modified "2023-09-27" @default.
- W1501636063 title "Neurochemical aspects of the receptor complex" @default.
- W1501636063 cites W10673897 @default.
- W1501636063 cites W1502203497 @default.
- W1501636063 cites W1505997555 @default.
- W1501636063 cites W1531501778 @default.
- W1501636063 cites W1541602774 @default.
- W1501636063 cites W1556569805 @default.
- W1501636063 cites W1592481675 @default.
- W1501636063 cites W1593069256 @default.
- W1501636063 cites W1595553662 @default.
- W1501636063 cites W1599662080 @default.
- W1501636063 cites W1910864442 @default.
- W1501636063 cites W1963718884 @default.
- W1501636063 cites W1964030958 @default.
- W1501636063 cites W1966621949 @default.
- W1501636063 cites W1966626021 @default.
- W1501636063 cites W1966751481 @default.
- W1501636063 cites W1967461691 @default.
- W1501636063 cites W1968951486 @default.
- W1501636063 cites W1968956259 @default.
- W1501636063 cites W1970377013 @default.
- W1501636063 cites W1970393142 @default.
- W1501636063 cites W1971502696 @default.
- W1501636063 cites W1972087864 @default.
- W1501636063 cites W1974374004 @default.
- W1501636063 cites W1974520231 @default.
- W1501636063 cites W1974903553 @default.
- W1501636063 cites W1975514155 @default.
- W1501636063 cites W1975911537 @default.
- W1501636063 cites W1977085933 @default.
- W1501636063 cites W1977928569 @default.
- W1501636063 cites W1978630220 @default.
- W1501636063 cites W1978989737 @default.
- W1501636063 cites W1979748602 @default.
- W1501636063 cites W1980079071 @default.
- W1501636063 cites W1980556950 @default.
- W1501636063 cites W1980672650 @default.
- W1501636063 cites W1980688136 @default.
- W1501636063 cites W1980781247 @default.
- W1501636063 cites W1984757732 @default.
- W1501636063 cites W1985569457 @default.
- W1501636063 cites W1985615482 @default.
- W1501636063 cites W1985867674 @default.
- W1501636063 cites W1985971264 @default.
- W1501636063 cites W1986233453 @default.
- W1501636063 cites W1987258940 @default.
- W1501636063 cites W1987897143 @default.
- W1501636063 cites W1989549476 @default.
- W1501636063 cites W1991505959 @default.
- W1501636063 cites W1991614175 @default.
- W1501636063 cites W1991647860 @default.
- W1501636063 cites W1992294190 @default.
- W1501636063 cites W1992301560 @default.
- W1501636063 cites W1992954084 @default.
- W1501636063 cites W1993419219 @default.
- W1501636063 cites W1994453614 @default.
- W1501636063 cites W1994662713 @default.
- W1501636063 cites W1995054580 @default.
- W1501636063 cites W1996128276 @default.
- W1501636063 cites W1996784761 @default.
- W1501636063 cites W1996838864 @default.
- W1501636063 cites W1996894437 @default.
- W1501636063 cites W1997568797 @default.
- W1501636063 cites W1998164097 @default.
- W1501636063 cites W1998305119 @default.
- W1501636063 cites W1998347917 @default.
- W1501636063 cites W2001201602 @default.
- W1501636063 cites W2001336176 @default.
- W1501636063 cites W2001653062 @default.
- W1501636063 cites W2001744744 @default.
- W1501636063 cites W2002632293 @default.
- W1501636063 cites W2002919913 @default.
- W1501636063 cites W2005396405 @default.
- W1501636063 cites W2005776786 @default.
- W1501636063 cites W2009121340 @default.
- W1501636063 cites W2009766398 @default.
- W1501636063 cites W2009782005 @default.
- W1501636063 cites W2010926499 @default.
- W1501636063 cites W2011176838 @default.
- W1501636063 cites W2011251926 @default.
- W1501636063 cites W2011999599 @default.
- W1501636063 cites W2012387292 @default.
- W1501636063 cites W2013920442 @default.
- W1501636063 cites W2013933144 @default.
- W1501636063 cites W2017036295 @default.
- W1501636063 cites W2017439595 @default.
- W1501636063 cites W2017635992 @default.
- W1501636063 cites W2018883950 @default.
- W1501636063 cites W2019383025 @default.
- W1501636063 cites W2019767334 @default.
- W1501636063 cites W2020749289 @default.
- W1501636063 cites W2021445983 @default.