FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1501722970> ?p ?o ?g. }

• W1501722970 endingPage "221" @default.
• W1501722970 startingPage "212" @default.
• W1501722970 abstract "We have previously shown that lipid mediators, produced by phospholipase D and C, are generated in OX(1) orexin receptor signalling with high potency, and presumably mediate some of the physiological responses to orexin. In this study, we investigated whether the ubiquitous phospholipase A(2) (PLA(2)) signalling system is also involved in orexin receptor signalling.Recombinant Chinese hamster ovary-K1 cells, expressing human OX(1) receptors, were used as a model system. Arachidonic acid (AA) release was measured from (3)H-AA-labelled cells. Ca(2+) signalling was assessed using single-cell imaging.Orexins strongly stimulated [(3)H]-AA release (maximally 4.4-fold). Orexin-A was somewhat more potent than orexin-B (pEC(50) = 8.90 and 8.38 respectively). The concentration-response curves appeared biphasic. The release was fully inhibited by the potent cPLA(2) and iPLA(2) inhibitor, methyl arachidonyl fluorophosphonate, whereas the iPLA(2) inhibitors, R- and S-bromoenol lactone, caused only a partial inhibition. The response was also fully dependent on Ca(2+) influx, and the inhibitor studies suggested involvement of the receptor-operated influx pathway. The receptor-operated pathway, on the other hand, was partially dependent on PLA(2) activity. The extracellular signal-regulated kinase, but not protein kinase C, were involved in the PLA(2) activation at low orexin concentrations.Activation of OX(1) orexin receptors induced a strong, high-potency AA release, possibly via multiple PLA(2) species, and this response may be important for the receptor-operated Ca(2+) influx. The response coincided with other high-potency lipid messenger responses, and may interact with these signals." @default.
• W1501722970 created "2016-06-24" @default.
• W1501722970 creator A5039498150 @default.
• W1501722970 creator A5062920007 @default.
• W1501722970 creator A5080765918 @default.
• W1501722970 creator A5085487847 @default.
• W1501722970 date "2010-01-01" @default.
• W1501722970 modified "2023-10-17" @default.
• W1501722970 title "Arachidonic acid release mediated by OX₁ orexin receptors" @default.
• W1501722970 cites W1253179 @default.
• W1501722970 cites W1513722678 @default.
• W1501722970 cites W1764472238 @default.
• W1501722970 cites W1966556984 @default.
• W1501722970 cites W1969581325 @default.
• W1501722970 cites W1980380395 @default.
• W1501722970 cites W1985579250 @default.
• W1501722970 cites W1986447940 @default.
• W1501722970 cites W1995692886 @default.
• W1501722970 cites W2005133982 @default.
• W1501722970 cites W2014826286 @default.
• W1501722970 cites W2018136812 @default.
• W1501722970 cites W2027321140 @default.
• W1501722970 cites W2027721701 @default.
• W1501722970 cites W2027740042 @default.
• W1501722970 cites W2030296716 @default.
• W1501722970 cites W2033547042 @default.
• W1501722970 cites W2034770942 @default.
• W1501722970 cites W2043463611 @default.
• W1501722970 cites W2047308870 @default.
• W1501722970 cites W2051726070 @default.
• W1501722970 cites W2066600235 @default.
• W1501722970 cites W2067025602 @default.
• W1501722970 cites W2070626143 @default.
• W1501722970 cites W2072346518 @default.
• W1501722970 cites W2075744025 @default.
• W1501722970 cites W2081128554 @default.
• W1501722970 cites W2083681924 @default.
• W1501722970 cites W2083977901 @default.
• W1501722970 cites W2090621246 @default.
• W1501722970 cites W2093753608 @default.
• W1501722970 cites W2096310704 @default.
• W1501722970 cites W2104631706 @default.
• W1501722970 cites W2105372376 @default.
• W1501722970 cites W2129911403 @default.
• W1501722970 cites W2130717252 @default.
• W1501722970 cites W2132305492 @default.
• W1501722970 cites W2163162884 @default.
• W1501722970 cites W2164675383 @default.
• W1501722970 cites W4231241402 @default.
• W1501722970 cites W4248635034 @default.
• W1501722970 doi "https://doi.org/10.1111/j.1476-5381.2009.00535.x" @default.
• W1501722970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2823366" @default.
• W1501722970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20002100" @default.
• W1501722970 hasPublicationYear "2010" @default.
• W1501722970 type Work @default.
• W1501722970 sameAs 1501722970 @default.
• W1501722970 citedByCount "31" @default.
• W1501722970 countsByYear W15017229702012 @default.
• W1501722970 countsByYear W15017229702013 @default.
• W1501722970 countsByYear W15017229702014 @default.
• W1501722970 countsByYear W15017229702016 @default.
• W1501722970 countsByYear W15017229702017 @default.
• W1501722970 countsByYear W15017229702019 @default.
• W1501722970 countsByYear W15017229702021 @default.
• W1501722970 countsByYear W15017229702022 @default.
• W1501722970 countsByYear W15017229702023 @default.
• W1501722970 crossrefType "journal-article" @default.
• W1501722970 hasAuthorship W1501722970A5039498150 @default.
• W1501722970 hasAuthorship W1501722970A5062920007 @default.
• W1501722970 hasAuthorship W1501722970A5080765918 @default.
• W1501722970 hasAuthorship W1501722970A5085487847 @default.
• W1501722970 hasBestOaLocation W15017229701 @default.
• W1501722970 hasConcept C118303440 @default.
• W1501722970 hasConcept C126322002 @default.
• W1501722970 hasConcept C134018914 @default.
• W1501722970 hasConcept C170493617 @default.
• W1501722970 hasConcept C175656101 @default.
• W1501722970 hasConcept C181199279 @default.
• W1501722970 hasConcept C185592680 @default.
• W1501722970 hasConcept C2778078955 @default.
• W1501722970 hasConcept C2778597717 @default.
• W1501722970 hasConcept C2779605129 @default.
• W1501722970 hasConcept C2779680196 @default.
• W1501722970 hasConcept C55493867 @default.
• W1501722970 hasConcept C62478195 @default.
• W1501722970 hasConcept C71924100 @default.
• W1501722970 hasConcept C86803240 @default.
• W1501722970 hasConcept C95444343 @default.
• W1501722970 hasConceptScore W1501722970C118303440 @default.
• W1501722970 hasConceptScore W1501722970C126322002 @default.
• W1501722970 hasConceptScore W1501722970C134018914 @default.
• W1501722970 hasConceptScore W1501722970C170493617 @default.
• W1501722970 hasConceptScore W1501722970C175656101 @default.
• W1501722970 hasConceptScore W1501722970C181199279 @default.
• W1501722970 hasConceptScore W1501722970C185592680 @default.
• W1501722970 hasConceptScore W1501722970C2778078955 @default.
• W1501722970 hasConceptScore W1501722970C2778597717 @default.
• W1501722970 hasConceptScore W1501722970C2779605129 @default.

• next