FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1501764680> ?p ?o ?g. }

• W1501764680 endingPage "1616" @default.
• W1501764680 startingPage "1605" @default.
• W1501764680 abstract "Sphingosine kinase 1 catalyses formation of the bioactive lipid, sphingosine 1-phosphate, which protects cancer cells from apoptosis. Therefore, sphingosine kinase 1 is a novel target for intervention with anti-cancer agents. We have assessed the effect of the anti-cancer agent, resveratrol and its dimers (ampelopsin A and balanocarpol) on sphingosine kinase 1 activity and on survival of MCF-7 breast cancer cells.Ampelopsin A and balanocarpol were purified from Hopea dryobalanoides and their effect on sphingosine kinase 1 activity and expression, [(3)H] thymidine incorporation, ERK-1/2 phosphorylation and PARP activity assessed in MCF-7 cells.Resveratrol, ampelopsin A and balanocarpol were novel inhibitors of sphingosine kinase 1 activity. Balanocarpol was a mixed inhibitor (with sphingosine) of sphingosine kinase 1 with a K(ic) = 90 ± 10 µM and a K(iu) of ∼500 µM. Balanocarpol and ampelopsin A also induced down-regulation of sphingosine kinase 1 expression and reduced DNA synthesis, while balanocarpol stimulated PARP cleavage in MCF-7 breast cancer cells. Resveratrol was a competitive inhibitor (with sphingosine) of sphingosine kinase 1 with a K(ic) = 160 ± 40 µM, reduced sphingosine kinase 1 expression and induced PARP cleavage in MCF-7 cells.Each molecule of balanocarpol may bind at least two sphingosine kinase 1 catalytic molecules to reduce the activity of each simultaneously. These findings suggest that resveratrol, ampelopsin A and balanocarpol could perturb sphingosine kinase 1-mediated signalling and this might explain their activity against MCF-7 breast cancer cells." @default.
• W1501764680 created "2016-06-24" @default.
• W1501764680 creator A5000512250 @default.
• W1501764680 creator A5004191810 @default.
• W1501764680 creator A5023834954 @default.
• W1501764680 creator A5060561968 @default.
• W1501764680 date "2012-06-21" @default.
• W1501764680 modified "2023-09-24" @default.
• W1501764680 title "Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival" @default.
• W1501764680 cites W1973576387 @default.
• W1501764680 cites W1976443089 @default.
• W1501764680 cites W1979501382 @default.
• W1501764680 cites W1981493008 @default.
• W1501764680 cites W1983079076 @default.
• W1501764680 cites W1989969820 @default.
• W1501764680 cites W1997458456 @default.
• W1501764680 cites W2002694320 @default.
• W1501764680 cites W2003231937 @default.
• W1501764680 cites W2007110714 @default.
• W1501764680 cites W2020730385 @default.
• W1501764680 cites W2023293937 @default.
• W1501764680 cites W2037074869 @default.
• W1501764680 cites W2039428118 @default.
• W1501764680 cites W2043847489 @default.
• W1501764680 cites W2045486084 @default.
• W1501764680 cites W2045716810 @default.
• W1501764680 cites W2050625990 @default.
• W1501764680 cites W2051863666 @default.
• W1501764680 cites W2058750636 @default.
• W1501764680 cites W2060814375 @default.
• W1501764680 cites W2063551469 @default.
• W1501764680 cites W2078794107 @default.
• W1501764680 cites W2079996883 @default.
• W1501764680 cites W2088381487 @default.
• W1501764680 cites W2090762797 @default.
• W1501764680 cites W2090932918 @default.
• W1501764680 cites W2093206783 @default.
• W1501764680 cites W2097202436 @default.
• W1501764680 cites W2097791313 @default.
• W1501764680 cites W2125121177 @default.
• W1501764680 cites W2132587070 @default.
• W1501764680 cites W2133470606 @default.
• W1501764680 cites W2136830554 @default.
• W1501764680 cites W2151089147 @default.
• W1501764680 cites W2154587590 @default.
• W1501764680 cites W2159775348 @default.
• W1501764680 cites W4239873491 @default.
• W1501764680 doi "https://doi.org/10.1111/j.1476-5381.2012.01862.x" @default.
• W1501764680 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3419905" @default.
• W1501764680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22251058" @default.
• W1501764680 hasPublicationYear "2012" @default.
• W1501764680 type Work @default.
• W1501764680 sameAs 1501764680 @default.
• W1501764680 citedByCount "54" @default.
• W1501764680 countsByYear W15017646802012 @default.
• W1501764680 countsByYear W15017646802013 @default.
• W1501764680 countsByYear W15017646802014 @default.
• W1501764680 countsByYear W15017646802015 @default.
• W1501764680 countsByYear W15017646802016 @default.
• W1501764680 countsByYear W15017646802017 @default.
• W1501764680 countsByYear W15017646802018 @default.
• W1501764680 countsByYear W15017646802019 @default.
• W1501764680 countsByYear W15017646802020 @default.
• W1501764680 countsByYear W15017646802021 @default.
• W1501764680 countsByYear W15017646802022 @default.
• W1501764680 countsByYear W15017646802023 @default.
• W1501764680 crossrefType "journal-article" @default.
• W1501764680 hasAuthorship W1501764680A5000512250 @default.
• W1501764680 hasAuthorship W1501764680A5004191810 @default.
• W1501764680 hasAuthorship W1501764680A5023834954 @default.
• W1501764680 hasAuthorship W1501764680A5060561968 @default.
• W1501764680 hasBestOaLocation W15017646802 @default.
• W1501764680 hasConcept C170493617 @default.
• W1501764680 hasConcept C180899940 @default.
• W1501764680 hasConcept C181199279 @default.
• W1501764680 hasConcept C184235292 @default.
• W1501764680 hasConcept C185592680 @default.
• W1501764680 hasConcept C2776596873 @default.
• W1501764680 hasConcept C2776816829 @default.
• W1501764680 hasConcept C2777550365 @default.
• W1501764680 hasConcept C2777700496 @default.
• W1501764680 hasConcept C2778703144 @default.
• W1501764680 hasConcept C55493867 @default.
• W1501764680 hasConcept C86803240 @default.
• W1501764680 hasConceptScore W1501764680C170493617 @default.
• W1501764680 hasConceptScore W1501764680C180899940 @default.
• W1501764680 hasConceptScore W1501764680C181199279 @default.
• W1501764680 hasConceptScore W1501764680C184235292 @default.
• W1501764680 hasConceptScore W1501764680C185592680 @default.
• W1501764680 hasConceptScore W1501764680C2776596873 @default.
• W1501764680 hasConceptScore W1501764680C2776816829 @default.
• W1501764680 hasConceptScore W1501764680C2777550365 @default.
• W1501764680 hasConceptScore W1501764680C2777700496 @default.
• W1501764680 hasConceptScore W1501764680C2778703144 @default.
• W1501764680 hasConceptScore W1501764680C55493867 @default.
• W1501764680 hasConceptScore W1501764680C86803240 @default.
• W1501764680 hasIssue "5" @default.
• W1501764680 hasLocation W15017646801 @default.

• next