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- W1501775624 abstract "Increasing intra-abdominal pressure (IAP) is associated with a decrease in renal blood flow [1]. Abdominal perfusion pressure (APP) is calculated as the mean arterial pressure (MAP) – IAP. We investigated whether restoration of APP in dogs with the use of vasopressin (VP) and norepinephrine (NE) could increase renal blood flow under conditions of raised IAP.MethodsTen mongrel dogs (average weight 20 ± 3 kg) were anaesthetized and mechanically ventilated with 100% oxygen and halothane. The IAP was altered by filling a 3 l intraperitoneal bag with varying volumes of normal saline and the IAP was measured by the urinary catheter technique. Ultrasonic transit-time flow probes were placed around the ascending aorta and left renal artery. After baseline readings, the IAP was increased to 10, 20 and 30 mmHg. Preload was maintained by a continuous infusion of 500 ml/hour normal saline. At each level of IAP, the MAP was restored to achieve the baseline APP with VP and NE infusion, followed by decompression. The MAP, IAP, and renal blood flow (RBF) were measured." @default.
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- W1501775624 date "2006-01-01" @default.
- W1501775624 modified "2023-09-27" @default.
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- W1501775624 doi "https://doi.org/10.1186/cc4658" @default.
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