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- W1501892123 abstract "This chapter focuses on the growth factors in the central nervous system (CNS) and discusses their effects on oligodendroglia. Ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), neurotrophin-3 (NT-3), platelet derived growth factor (PDGF), and brain derived neurotrophic factor (BDNF) are the growth factors that enhance oligodendrocyte survival in vitro, and thus may provide therapeutic benefits for patients suffering from demyelinating diseases. A potential caveat, however, to the exogenous use of CNTF and LIF in vivo is their influence on cell differentiation. Limitations to growth factor function may be observed within an in vivo context. Cell culture studies often display pleiotropic actions for a given growth factor; but this is an artificial environment and may not necessarily represent their actions in vivo. In addition to cell-type specificity, the influence of growth factors in vivo is limited by their developmental, physiological, and pathological profiles of expression. Potential target cells must also express the appropriate growth factor receptor. Thus, although these growth factors appear to have pleiotropic actions in vitro, it is likely that their actions will be restricted by an in vivo setting. The identification of growth factor receptors and the location of their ligands in vivo will increase the understanding of growth factor function and bridge the gap between in vitro and in vivo studies." @default.
- W1501892123 created "2016-06-24" @default.
- W1501892123 creator A5041633348 @default.
- W1501892123 creator A5081730976 @default.
- W1501892123 date "1995-01-01" @default.
- W1501892123 modified "2023-09-25" @default.
- W1501892123 title "Chapter 13 Growth factors in the CNS and their effects on oligodendroglia" @default.
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