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- W1501928213 abstract "This chapter discusses the functional significance of heterogeneous prenyl processing of the heterotrimeric g protein gamma subunits in terms of the past biochemical characterization of the constituent reactions of the protein prenylation modifications. The heterotrimeric G proteins contain one member each from three small gene families with 16 Gα, 5 Gβ, and 12 Gγ genes coded for in the human genome. They mediate the cellular effects of many hormones, neurotransmitters, sensory stimuli, and other extracellular regulators, including the effects of many drugs. The small (7–9 kDa) Gγ subunits are all prenylated proteins. Prenylation is necessary for or a component of most membrane and protein–protein interactions required for signaling by these proteins. As sites of protein–protein interaction, in concert with amino acid sequences at the C-terminus of Gγ, these variations may lead to highly variable protein interaction sites that can interact with both upstream and downstream signaling partners in ways that are complex and, in the end, specific for each of the 12 Gγ isoforms found in the human genome. The chapter discusses some of the variation that can be observed for native proteins in each of the three constituent reactions associated with protein prenylation. A criticism of the significance of these observations is that these variant forms often represent minor components of the general population of G proteins observed." @default.
- W1501928213 created "2016-06-24" @default.
- W1501928213 creator A5033234998 @default.
- W1501928213 date "2011-01-01" @default.
- W1501928213 modified "2023-10-16" @default.
- W1501928213 title "Heterogeneous Prenyl Processing of the Heterotrimeric G protein Gamma Subunits" @default.
- W1501928213 cites W11457742 @default.
- W1501928213 cites W1482237901 @default.
- W1501928213 cites W1482653638 @default.
- W1501928213 cites W1486791172 @default.
- W1501928213 cites W1487258982 @default.
- W1501928213 cites W1490670694 @default.
- W1501928213 cites W1492777072 @default.
- W1501928213 cites W1498034410 @default.
- W1501928213 cites W1499914765 @default.
- W1501928213 cites W1508955850 @default.
- W1501928213 cites W1512691892 @default.
- W1501928213 cites W1517546728 @default.
- W1501928213 cites W1523056580 @default.
- W1501928213 cites W1530195638 @default.
- W1501928213 cites W1532747508 @default.
- W1501928213 cites W1535685087 @default.
- W1501928213 cites W1549892775 @default.
- W1501928213 cites W1570939625 @default.
- W1501928213 cites W1586989338 @default.
- W1501928213 cites W1598352138 @default.
- W1501928213 cites W1603074658 @default.
- W1501928213 cites W1604834232 @default.
- W1501928213 cites W1681309649 @default.
- W1501928213 cites W181525583 @default.
- W1501928213 cites W1837548662 @default.
- W1501928213 cites W1964667616 @default.
- W1501928213 cites W1965404955 @default.
- W1501928213 cites W1966020826 @default.
- W1501928213 cites W1967787845 @default.
- W1501928213 cites W1968453135 @default.
- W1501928213 cites W1972416441 @default.
- W1501928213 cites W1974302575 @default.
- W1501928213 cites W1975645593 @default.
- W1501928213 cites W1975702431 @default.
- W1501928213 cites W1976310120 @default.
- W1501928213 cites W1978392336 @default.
- W1501928213 cites W1978789853 @default.
- W1501928213 cites W1981722915 @default.
- W1501928213 cites W1981956283 @default.
- W1501928213 cites W1985459812 @default.
- W1501928213 cites W1986587815 @default.
- W1501928213 cites W1986827801 @default.
- W1501928213 cites W1990524685 @default.
- W1501928213 cites W1990847659 @default.
- W1501928213 cites W1991867962 @default.
- W1501928213 cites W1992055378 @default.
- W1501928213 cites W1993534516 @default.
- W1501928213 cites W1998865212 @default.
- W1501928213 cites W2003267467 @default.
- W1501928213 cites W2004799153 @default.
- W1501928213 cites W2006740795 @default.
- W1501928213 cites W2007472609 @default.
- W1501928213 cites W2010207338 @default.
- W1501928213 cites W2010946010 @default.
- W1501928213 cites W2012765001 @default.
- W1501928213 cites W2014018734 @default.
- W1501928213 cites W2015997081 @default.
- W1501928213 cites W2016209933 @default.
- W1501928213 cites W2016542329 @default.
- W1501928213 cites W2016644494 @default.
- W1501928213 cites W2016983896 @default.
- W1501928213 cites W2017098460 @default.
- W1501928213 cites W2026565430 @default.
- W1501928213 cites W2027764322 @default.
- W1501928213 cites W2028815025 @default.
- W1501928213 cites W2031738820 @default.
- W1501928213 cites W2034135335 @default.
- W1501928213 cites W2035363409 @default.
- W1501928213 cites W2036405416 @default.
- W1501928213 cites W2036842366 @default.
- W1501928213 cites W2036974504 @default.
- W1501928213 cites W2037085464 @default.
- W1501928213 cites W2037112367 @default.
- W1501928213 cites W2038046515 @default.
- W1501928213 cites W2038684232 @default.
- W1501928213 cites W2039451581 @default.
- W1501928213 cites W2039837364 @default.
- W1501928213 cites W2043212034 @default.
- W1501928213 cites W2044775506 @default.
- W1501928213 cites W2049768914 @default.
- W1501928213 cites W2051626784 @default.
- W1501928213 cites W2052345945 @default.
- W1501928213 cites W2056965979 @default.
- W1501928213 cites W2057724275 @default.
- W1501928213 cites W2058729896 @default.
- W1501928213 cites W2058814612 @default.
- W1501928213 cites W2059218768 @default.
- W1501928213 cites W2059585924 @default.
- W1501928213 cites W2059659204 @default.
- W1501928213 cites W2059800438 @default.
- W1501928213 cites W2060026513 @default.
- W1501928213 cites W2064830600 @default.