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- W1502012956 abstract "Lithium dosage was examined in 3 age groups (⩽ 45 years, 46–64 years, ⩾ 65 years) of 78 inpatients, matched on relevant variables. Although mean steady-state lithium plasma levels showed no essential differences, mean daily lithium doses were significantly lower in the elderly. The ratio of weight-related lithium dose to plasma level showed a 36% decline with age (0.58, 0.46 and 0.37 1/kg, P < 0.0001, analysis of variance). Comparing different decades this ratio, indicating the dose required for a certain plasma level, displayed a clear-cut decrease at 50 years. This may be caused by age-related changes in apparent volume of distribution and/or in elimination half-life of lithium, the latter being the consequence of age-related decrease of glomerular filtration rate." @default.
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- W1502012956 date "1985-07-01" @default.
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- W1502012956 title "Lithium dosage in the elderly" @default.
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- W1502012956 doi "https://doi.org/10.1016/0165-0327(85)90002-3" @default.
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